| Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model. | |
| | |
MedLine Citation:
|
PMID: 21120655 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Nearly twenty years of experimental immunotherapy for malignant glioma yielded important insights in the mechanisms governing glioma immunology. Still considered promising, it is clear that immunotherapy does not on its own represent the magic bullet in glioma therapy. In this review, we summarize the major immunotherapeutic achievements in the mouse GL261 glioma model, which has emerged as the gold standard syngeneic model for experimental glioma therapy. Gene therapy, monoclonal antibody treatment, cytokine therapy, cell transfer strategies and dendritic cell therapy were hereby considered. Apart from the considerable progress made in understanding glioma immunology in this model, we also addressed its most pertinent issues and shortcomings. Despite these, the GL261 model will remain indispensable in glioma research since it is a fast, highly reproducible and easy-to-establish model system. |
| | |
Authors:
|
Wim Maes; Stefaan W Van Gool |
Related Documents
:
|
19897835 - Percentage of nonoverlapping corrected data. 17152175 - Structure and genesis of some hippocratic treatises. 22558495 - Cross-simulation between two pharmacokinetic models for the target-controlled infusion ... 22362545 - Assessing allometric models to predict vegetative growth of mango (mangifera indica; an... 7698075 - Pharmacokinetics, chemical interactions, and toxicological risk assessment in perspective. 22931175 - Factors affecting accident severity inside and outside urban areas in greece. |
Publication Detail:
|
Type: Journal Article Date: 2010-12-01 |
Journal Detail:
|
Title: Cancer immunology, immunotherapy : CII Volume: 60 ISSN: 1432-0851 ISO Abbreviation: Cancer Immunol. Immunother. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8605732 Medline TA: Cancer Immunol Immunother Country: Germany |
Other Details:
|
Languages: eng Pagination: 153-60 Citation Subset: IM |
Affiliation:
|
Laboratory of Experimental Immunology (WM and SWVG), Pediatric Hemato-oncology (SWVG), University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationships between coastal bacterioplankton growth rates and biomass production: comparison of le...
Next Document: Important Role of Catalase in the Production of ?-carotene by Recombinant Saccharomyces cerevisiae u...