| Experimental hypoxemic hypoxia: changes in R2* of brain parenchyma accurately reflect the combined effects of changes in arterial and cerebral venous oxygen saturation. | |
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MedLine Citation:
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PMID: 9498604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A two-dimensional T2*-weighted gradient-echo sequence was used to image the rat brain before and during graded hypoxemia. Changes in R2* (deltaR2*) with respect to the control state were calculated for brain parenchyma and were compared with changes in hemoglobin saturation measured from both arterial and jugular venous blood samples. DeltaR2* was first correlated with the changes in arterial (deltaYa) and venous (deltaYv) hemoglobin saturations individually. Although a general trend toward a linear relationship with deltaR2* was observed for both deltaYa and deltaYv, neither alone was strong (correlation coefficients r=0.71 and 0.75 for deltaYa and deltaYv, respectively, and standard errors of the regression (SER)=0.52 and 0.48 for deltaYa and deltaYv, respectively). However, when an "effective" cerebral blood hemoglobin saturation change (deltaYb) was constructed that takes into account the approximate weighting of the contributions from the arterial and venous phases of the circulation (deltaYb = 0.75 x deltaYv + 0.25 x deltaYa), a stronger correlation with deltaR2* was obtained and there was less variance (r=0.87 and SER=0.35). It is concluded that an appropriate weighting of the contributions of arterial and venous phases of the circulation must be taken into account in modeling the volume susceptibility effects of deoxyhemoglobin on R2* of brain parenchyma. In this way, a more accurate relationship between deltaR2* and deltaYb can be obtained. |
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Authors:
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W Lin; R P Paczynski; A Celik; K Kuppusamy; C Y Hsu; W J Powers |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 39 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-04-30 Completed Date: 1998-04-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 474-81 Citation Subset: IM |
Affiliation:
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Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Anoxia / blood*, metabolism Aorta, Thoracic Blood Volume Brain / metabolism* Carbon Dioxide / blood Cerebral Veins Cerebrovascular Circulation Cranial Sinuses Hemoglobins / metabolism Image Processing, Computer-Assisted Jugular Veins Magnetic Resonance Imaging* Male Oxygen / blood* Oxyhemoglobins / metabolism Rats Regression Analysis Subtraction Technique |
| Grant Support | |
ID/Acronym/Agency:
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NS35147/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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