Document Detail


Experimental hyperprolactinemia and hypoprolactinemia and human chorionic gonadotropin during early pregnancy.
MedLine Citation:
PMID:  7243090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of experimental hyperprolactinemia and hypoprolactinemia on human chorionic gonadotropin (hCG) concentration was studied in 34 healthy volunteers between weeks 6 and 11 of normal pregnancy. Hyperprolactinemia was induced in 12 women with 150 mg of sulpiride daily for 2 weeks; treatment led to a mean plasma prolactin (PRL) rise from 14.6 to 84.1 microgram/liter after 1 week and to 83.0 microgram/liter after 2 weeks. Hypoprolactinemia was effected in 11 women wit 5.0 to 7.5 mg of bromocriptine, daily for 2 weeks; treatment decreased the mean plasma prolactin from 19.2 to 6.0 microgram/liter after 1 week and to 5.2 microgram/liter after 2 weeks. These PRL changes were significant (P less than .001) in comparison with the plasma PRL concentrations in the 11 control women. Hyperprolactinemia induced by the sulpiride treatment was accompanied by a significant decrease in hCG concentration, whereas no difference in hCG was seen between hypoprolactinemia and control groups. This may suggest a synergistic action of hCG and PRL, or a direct effect of sulpiride on hCG, but the final mechanism and biologic importance of the phenomenon remain to be investigated.
Authors:
L Viinikka; S Kivinen; L Rönnberg; O Ylikorkala
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  57     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Bromocriptine / pharmacology
Chorionic Gonadotropin / blood*
Female
Humans
Pregnancy
Pregnancy Trimester, First
Prolactin / blood*
Sulpiride / pharmacology
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 15676-16-1/Sulpiride; 25614-03-3/Bromocriptine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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