Document Detail


Experimental hydrostatic pulmonary edema in rabbit lungs. Barrier lesions.
MedLine Citation:
PMID:  8466139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In excised rabbit lungs perfused with a 6% albumin solution, hydrostatic pulmonary edema was induced by moderate (about 14 mm Hg) and high increases (about 29 mm Hg) of capillary transmural pressure. Thereafter, lung tissue and proteinaceous edema fluid were fixed by vascular perfusion and analyzed by electron microscopy for possible lesions of the blood-gas barrier. The following observations appear noteworthy: (1) There were distinct and numerous lesions of the epithelial cell layer. In high-pressure edema, frank disruptions on the thin and thick sides of the blood-gas barrier were prominent. In moderate pressure edema epithelial blebs were more conspicuous. (2) In contrast, endothelial lesions were rare in both high- and moderate-pressure experiments. (3) Epithelial Type I cells revealed an enormous plasticity as illustrated by the formation of large epithelial blebs. (4) Although the entire microvasculature was subjected to high pressures, barrier lesions were exclusively seen in regions with alveolar edema. These findings suggest that barrier leaks play a role in both hydrostatic and permeability lung edema and that the differences between both types of edema rather reflects the type and extent of injury to the alveolar epithelial barrier and the associated inflammatory reaction.
Authors:
H Bachofen; S Schürch; E R Weibel
Related Documents :
8173749 - Effect of hypoxia on lung fluid balance in ferrets.
7360519 - Sequential effects of acute meconium obstruction on pulmonary function.
7990719 - Effect of erythrocyte heat treatment on pulmonary vascular resistance.
7436009 - The effects of desiccated thyroid on the rat lung.
1986399 - Early radiation response of the canine heart and lung.
15258499 - Acute respiratory distress syndrome, the critical care paradigm: what we learned and wh...
12865149 - Method for in vivo calibration of renal sympathetic nerve activity in rabbits.
21224409 - Sensory transduction in human teeth with inflamed pulps.
23904429 - Uterine torsion mimicking supine hypotension syndrome after regional anaesthesia.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  147     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-04-30     Completed Date:  1993-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  997-1004     Citation Subset:  AIM; IM    
Affiliation:
Department of Anatomy, University of Berne, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Epithelium / ultrastructure
Hydrostatic Pressure
Lung / ultrastructure*
Pulmonary Alveoli / ultrastructure
Pulmonary Edema / etiology,  pathology*
Rabbits
Comments/Corrections
Comment In:
Am Rev Respir Dis. 1993 Apr;147(4):790-2   [PMID:  8466110 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Experimental hydrostatic pulmonary edema in rabbit lungs. Morphology.
Next Document:  Laboratory diagnosis of phaeochromocytoma: which analytes should we measure?