Document Detail

Experimental gram-negative pneumonia produces a hyperdynamic septic profile.
MedLine Citation:
PMID:  3652394     Owner:  NLM     Status:  MEDLINE    
General anesthesia (GA) and extensive surgery undertaken to reproduce a hyperdynamic septic shock syndrome (HSSS) may confound the observed effects of pure HSSS. A large animal model of HSSS without GA or surgery was created in sheep following production of a Pseudomonas pneumonia by direct bronchoscopic instillation into a dependent lobe using only light ketamine anesthesia. Cardiac output rose significantly (5.05 to 6.32 L/min) while SVR [1,421.4 to 1,000.5 dynes X s X cm(-5)] and mean BP (92.5 to 82.0 mmHg) fell in the septic animals. Systemic infection was confirmed by blood culture. This model reliably produces hyperdynamic sepsis without the confounding effects of GA or extensive surgery.
R J Keenan; T R Todd; M J Girotti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulatory shock     Volume:  22     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-18     Completed Date:  1987-11-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-9     Citation Subset:  IM    
Department of Surgery, Toronto General Hospital, Ontario, Canada.
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MeSH Terms
Disease Models, Animal
Oxygen / blood
Pneumonia / etiology,  physiopathology*
Pseudomonas Infections / physiopathology*
Shock, Septic / etiology,  physiopathology*
Reg. No./Substance:

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