| Experimental glomerulonephritis following successive inoculation of five different serotypes of group B coxsackieviruses in mice. | |
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MedLine Citation:
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PMID: 9380244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present investigation is to study renal injury by monthly viral inoculation into mice, using several different types of strains of enterovirus. A group of mice were inoculated intravenously with five different serotypes of group B coxsackieviruses (CB1 to CB5), once a month from 1 to 5 months of age and sacrificed monthly from 6 to 12 months of age. Mesangial proliferation and PAS-positive mesangial deposits in light microscopy and electron-dense deposits in electron microscopy were observed at maximum from 6 to 7 months of age. The CB viral RNA detected by in situ hybridization were observed in the mesangial lesion. By immunofluorescence findings, positive findings for IgG and IgA were observed. These results demonstrated that intermittent intravenous inoculation with different serotypes CB in mice provoked pathological changes closely resembling those in human proliferative glomerulonephritis. Moreover, the detection of CB viral RNA in glomerular lesions suggested that renal injury was induced by immune complexes correlated with CB viral replication in renal tissues. |
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Authors:
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M Isome; K Yoshida; S Suzuki; K Kume; J Suzuki; K Kato; H Suzuki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephron Volume: 77 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1997 |
Date Detail:
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Created Date: 1997-11-10 Completed Date: 1997-11-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 93-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Fukushima Medical College, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / immunology Antigens, Viral / immunology* Enterovirus B, Human / immunology* Female Fluorescent Antibody Technique, Indirect Glomerulonephritis / etiology*, immunology*, pathology In Situ Hybridization Kidney / metabolism Mice Mice, Inbred ICR Microscopy, Electron Proteinuria / chemically induced RNA, Viral / biosynthesis, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Antigens, Viral; 0/RNA, Viral |
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