| Experimental freeze-dried microarterial allografts in rabbits. | |
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MedLine Citation:
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PMID: 3606846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arterial allografts, 3.5 cm in length, were freeze-dried and placed into the femoral arteries of 20 female rabbits (16 experimental subjects and four controls). Immediate patency was 100%. Subjects were surgically explored after two months of observation. Overall patency at this time was 31% (5/16). A patency rate of 50% (5/10) was achieved with size-matched femoral grafts. However, all of the smaller diameter brachial grafts were unsuccessful. Analysis by light microscopy as well as transmission and scanning electron microscopy demonstrated intimal hyperplasia, which was more prominent in nonpatent grafts. There was no evidence of a cellular immune response to the freeze-dried grafts by the host. The use of size-matched grafts and postoperative anticoagulants in future studies may improve patency rates and the potential clinical applicability of this promising microvascular technique. |
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Authors:
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M F Pratt; J R Schneider; F R Galey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of otolaryngology--head & neck surgery Volume: 113 ISSN: 0886-4470 ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1987-09-21 Completed Date: 1987-09-21 Revised Date: 2006-03-28 |
Medline Journal Info:
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Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 953-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / transplantation* Arterioles / transplantation*, ultrastructure Female Freeze Drying* Microscopy, Electron Microscopy, Electron, Scanning Rabbits Tissue Preservation / methods* Vascular Patency |
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