Document Detail

Experimental freeze-dried microarterial allografts in rabbits.
MedLine Citation:
PMID:  3606846     Owner:  NLM     Status:  MEDLINE    
Arterial allografts, 3.5 cm in length, were freeze-dried and placed into the femoral arteries of 20 female rabbits (16 experimental subjects and four controls). Immediate patency was 100%. Subjects were surgically explored after two months of observation. Overall patency at this time was 31% (5/16). A patency rate of 50% (5/10) was achieved with size-matched femoral grafts. However, all of the smaller diameter brachial grafts were unsuccessful. Analysis by light microscopy as well as transmission and scanning electron microscopy demonstrated intimal hyperplasia, which was more prominent in nonpatent grafts. There was no evidence of a cellular immune response to the freeze-dried grafts by the host. The use of size-matched grafts and postoperative anticoagulants in future studies may improve patency rates and the potential clinical applicability of this promising microvascular technique.
M F Pratt; J R Schneider; F R Galey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  113     ISSN:  0886-4470     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-09-21     Completed Date:  1987-09-21     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  953-8     Citation Subset:  AIM; IM    
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MeSH Terms
Arteries / transplantation*
Arterioles / transplantation*,  ultrastructure
Freeze Drying*
Microscopy, Electron
Microscopy, Electron, Scanning
Tissue Preservation / methods*
Vascular Patency

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