Document Detail

Experimental forward mandibular displacement in sheep.
MedLine Citation:
PMID:  11743935     Owner:  NLM     Status:  MEDLINE    
In order to investigate growth modifications of the temporomandibular joint (TMJ) during dentofacial orthopaedic treatment, specific functional appliances have been used experimentally to prompt the mandible into a protrusive position in various animal models. The purpose of this study was to test the effectiveness of a functional appliance specially designed for sheep and to evaluate the sheep as a model for dentofacial orthopaedic research. Eight, 4-month-old, castrated male Merino sheep were randomly assigned to experimental or control groups, with four in each group. Cast functional appliances were fabricated for the animals in the experimental group. The treatment period was 15 weeks. Dental casts, endosseous implant markers and cephalograms were used to analyse the displacement of the mandible. Undemineralised sagittal sections of TMJ were used to evaluate the tissue responses induced by the appliances. The weight of the animals was measured monthly to monitor their growth. The growth of the metacarpus was also measured. During the experimental period, the animals maintained their weight within the normal range and grew normally. The appliance displaced the mandible to a downward and forward position. The adaptive responses in the TMJ induced by the appliances included changed anteroposterior shape of the condylar process, anteriorly thickened condylar cartilage, and a thickened compact bone layer along the anterior surface of the posterior wall of the glenoid fossa. The sheep coped well with the experimental procedures and the appliance used was demonstrably effective in inducing adaptive responses in the TMJ. Consequently, it is believed that the sheep is an appropriate animal model to study growth modifications in the TMJ region.
Bingkui Ma; Wayne Sampson; Nicola Fazzalari; David Wilson; Ole Wiebkin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of oral biology     Volume:  47     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  D; IM    
Orthodontic Unit, Dental School, Faculty of Health Sciences, Adelaide University, SA 5005, Adelaide, Australia.
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MeSH Terms
Adaptation, Physiological
Body Weight
Cartilage, Articular / growth & development,  pathology
Dental Implants
Dental Models
Fluoresceins / diagnostic use
Fluorescent Dyes / diagnostic use
Mandible / growth & development,  pathology*
Mandibular Condyle / growth & development,  pathology
Metacarpus / growth & development
Models, Animal
Orthodontic Appliance Design
Orthodontic Appliances, Functional*
Orthodontics, Corrective / instrumentation*
Random Allocation
Statistics as Topic
Temporal Bone / growth & development,  pathology
Temporomandibular Joint / growth & development,  pathology*
Reg. No./Substance:
0/Dental Implants; 0/Fluoresceins; 0/Fluorescent Dyes; 1461-15-0/fluorexon

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