| Experimental evaluation of the extent of myocardial dyssynergy and infarct size by two-dimensional echocardiography. | |
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MedLine Citation:
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PMID: 7460247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extent of left ventricular (LV) dyssynergy was assessed noninvasively in 19 dogs with two-dimensional echocardiographic short-axis sections during myocardial ischemia and infarction. After coronary occlusion, two-dimensional echocardiography uniformly indicated an increase in LV end-diastolic volume and a decrease in LV ejection fraction. Two-dimensional echocardiographic measurements of dyssynergy were evaluated and compared in three subgroups against (1) the extent of LV dyssynergy determined by force-gauge mapping during 10 coronary occlusions of 30-60 minutes' duration in eight open-chest dogs, (2) infarct size delineated by nitroblue tetrazolium (NBT) staining of left ventricular slabs after 48 hours of left anterior descending coronary artery (LAD) occlusion in five closed-chest dogs, and (3) NBT infarct size after 3-hour LAD occlusion followed by 45 hours of reperfusion in six closed-chest dogs. Linear regression analysis of results from these three comparisons gave good correlations (r = 0.89) for groups 1 and 2; in group 2, the extent of dyssynergy by two-dimensional echocardiography was consistently greater than infarct size by NBT. In group 3, the correlation was poor (r = 0.39). These results suggest that an adequate estimate for the extent of LV dyssynergy or infarct size may be obtained with two-dimensional echocardiography during myocardial ischemia or infarction, but not in the presence of coronary reflow, which causes an acute discrepancy between myocardial viability and function. |
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Authors:
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H L Wyatt; S Meerbaum; M K Heng; J Rit; P Gueret; E Corday |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 63 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-04-21 Completed Date: 1981-04-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 607-14 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / diagnosis Coronary Vessels Dogs Echocardiography* Heart Ventricles Myocardial Contraction* Myocardial Infarction / diagnosis* Nitroblue Tetrazolium / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL 14644-07/HL/NHLBI NIH HHS; HL 17651-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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298-83-9/Nitroblue Tetrazolium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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