| Experimental evaluation of early and long-term effects of microparticle embolization in two different mini-pig models. Part II: liver. | |
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MedLine Citation:
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PMID: 17342551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate trisacryl-gelatin microspheres (40-120 microm) for acute and chronic tissue embolization in mini-pig livers. METHODS: Thirteen animals were divided into four groups: group 1 (n = 3), total arterial bed occlusion with acute procedure; groups 2 to 4, chronic superselective embolization with follow-up of 1 week (group 2, n = 1), 4 weeks (group 3, n = 4) or 14 weeks (group 4, n = 5). Key endpoints were homogeneity and particle distribution in acute embolizations (group 1) and necrosis and inflammation in chronic embolizations (groups 2-4) as assessed microscopically and angiographically. RESULTS: After liver embolization, parenchymal necrosis did not occur; only signs of vessel wall disintegration were evident. The bile ducts remained intact. A distinct foreign body reaction with sparse leukocytic infiltration and giant cells was found at 14 weeks, but no signs of major inflammation were found. Particles were seen at the presinusoidal level, but no particle transportation into the sinusoids was observed. CONCLUSIONS: Embolization in mini-pig livers, using small trisacryl-gelatin microspheres, results in vessel fibrosis without parenchymal or bile duct necrosis. The most likely explanation for preservation of the parenchyma is portal inflow. Small trisacryl-gelatin microspheres may be ideal as an adjunct for chemoembolization. |
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Authors:
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S Stampfl; U Stampfl; C Rehnitz; Ph Schnabel; S Satzl; P Christoph; C Henn; F Thomas; G M Richter |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular and interventional radiology Volume: 30 ISSN: 0174-1551 ISO Abbreviation: Cardiovasc Intervent Radiol Publication Date: 2007 May-Jun |
Date Detail:
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Created Date: 2007-04-13 Completed Date: 2007-10-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003538 Medline TA: Cardiovasc Intervent Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 462-8 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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adverse effects,
therapeutic use* Animals Embolization, Therapeutic / methods* Foreign-Body Migration / pathology Foreign-Body Reaction / pathology Gelatin / adverse effects, therapeutic use* Hepatic Artery / pathology Liver / blood supply*, pathology Swine Swine, Miniature |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/trisacryl gelatin microspheres; 9000-70-8/Gelatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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