Document Detail


Experimental evaluation of early and long-term effects of microparticle embolization in two different mini-pig models. Part II: liver.
MedLine Citation:
PMID:  17342551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate trisacryl-gelatin microspheres (40-120 microm) for acute and chronic tissue embolization in mini-pig livers. METHODS: Thirteen animals were divided into four groups: group 1 (n = 3), total arterial bed occlusion with acute procedure; groups 2 to 4, chronic superselective embolization with follow-up of 1 week (group 2, n = 1), 4 weeks (group 3, n = 4) or 14 weeks (group 4, n = 5). Key endpoints were homogeneity and particle distribution in acute embolizations (group 1) and necrosis and inflammation in chronic embolizations (groups 2-4) as assessed microscopically and angiographically. RESULTS: After liver embolization, parenchymal necrosis did not occur; only signs of vessel wall disintegration were evident. The bile ducts remained intact. A distinct foreign body reaction with sparse leukocytic infiltration and giant cells was found at 14 weeks, but no signs of major inflammation were found. Particles were seen at the presinusoidal level, but no particle transportation into the sinusoids was observed. CONCLUSIONS: Embolization in mini-pig livers, using small trisacryl-gelatin microspheres, results in vessel fibrosis without parenchymal or bile duct necrosis. The most likely explanation for preservation of the parenchyma is portal inflow. Small trisacryl-gelatin microspheres may be ideal as an adjunct for chemoembolization.
Authors:
S Stampfl; U Stampfl; C Rehnitz; Ph Schnabel; S Satzl; P Christoph; C Henn; F Thomas; G M Richter
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  30     ISSN:  0174-1551     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-04-13     Completed Date:  2007-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  462-8     Citation Subset:  IM    
Affiliation:
Department of Diagnostic Radiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acrylic Resins / adverse effects,  therapeutic use*
Animals
Embolization, Therapeutic / methods*
Foreign-Body Migration / pathology
Foreign-Body Reaction / pathology
Gelatin / adverse effects,  therapeutic use*
Hepatic Artery / pathology
Liver / blood supply*,  pathology
Swine
Swine, Miniature
Chemical
Reg. No./Substance:
0/Acrylic Resins; 0/trisacryl gelatin microspheres; 9000-70-8/Gelatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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