Document Detail


Experimental evaluation of Tc-99m sulfur colloid as a potential imaging agent in thromboembolic disease: concise communication.
MedLine Citation:
PMID:  7400827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Based on literature reports suggesting the possible incorporation of Tc-99m sulfur colloid (Tc-SC) into fibrin deposits, this study was undertaken to evaluate the potential of this radiopharmaceutical as an imaging agent in thromboembolic disease. Animal models of deep-vein thrombosis and pulmonary embolism were used. The mean thrombus-to-blood (T/B) uptake ratios were comparable for fresh and older thrombi (up to 72 hr). Thrombus uptake was significantly lower in a group of five control dogs that received pertechnetate instead of Tc-SC. Intravenous heparin administration (5,000 IU) 2 hr before injection of Tc-SC caused a depression in T/B ratios but did not totally block Tc-SC uptake. Gamma imaging with Tc-SC allowed demonstration of deep-vein thrombi, but imaging of pulmonary emboli as areas of increased activity was not satisfactory. This study supports the concept of thrombus detection with radiolabeled particles but not the extension of this principle to the imaging of pulmonary emboli.
Authors:
F Vieras; E L Barron; G A Parker; M P Grissom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  21     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  723-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Colloids
Dogs
Evaluation Studies as Topic
Fibrin / metabolism
Heparin / pharmacology
Lung / radionuclide imaging
Pulmonary Embolism / metabolism,  radionuclide imaging
Sulfur / diagnostic use,  metabolism
Technetium / diagnostic use*,  metabolism
Thromboembolism / metabolism,  radionuclide imaging*
Thrombosis / metabolism,  radionuclide imaging
Time Factors
Chemical
Reg. No./Substance:
0/Colloids; 7440-26-8/Technetium; 7704-34-9/Sulfur; 9001-31-4/Fibrin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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