| Experimental evaluation of Tc-99m sulfur colloid as a potential imaging agent in thromboembolic disease: concise communication. | |
| | |
MedLine Citation:
|
PMID: 7400827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Based on literature reports suggesting the possible incorporation of Tc-99m sulfur colloid (Tc-SC) into fibrin deposits, this study was undertaken to evaluate the potential of this radiopharmaceutical as an imaging agent in thromboembolic disease. Animal models of deep-vein thrombosis and pulmonary embolism were used. The mean thrombus-to-blood (T/B) uptake ratios were comparable for fresh and older thrombi (up to 72 hr). Thrombus uptake was significantly lower in a group of five control dogs that received pertechnetate instead of Tc-SC. Intravenous heparin administration (5,000 IU) 2 hr before injection of Tc-SC caused a depression in T/B ratios but did not totally block Tc-SC uptake. Gamma imaging with Tc-SC allowed demonstration of deep-vein thrombi, but imaging of pulmonary emboli as areas of increased activity was not satisfactory. This study supports the concept of thrombus detection with radiolabeled particles but not the extension of this principle to the imaging of pulmonary emboli. |
| | |
Authors:
|
F Vieras; E L Barron; G A Parker; M P Grissom |
Related Documents
:
|
17227517 - Comparative study of conventional colonoscopy, chromoendoscopy, and narrow-band imaging... 22521707 - Electrocortical reactivity to emotional images and faces in middle childhood to early a... 9833577 - The value of thyroid parenchymal echogenicity as an indicator of pathology using the st... 6260497 - A multiobserver comparison of 99mtco4 and 123i thyroid imaging. 2627767 - An automated analysis technique for thallium images. 23564187 - A zernike-moment-based non-local denoising filter for cryo-em images. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 21 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1980 Aug |
Date Detail:
|
Created Date: 1980-10-27 Completed Date: 1980-10-27 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 723-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Colloids Dogs Evaluation Studies as Topic Fibrin / metabolism Heparin / pharmacology Lung / radionuclide imaging Pulmonary Embolism / metabolism, radionuclide imaging Sulfur / diagnostic use, metabolism Technetium / diagnostic use*, metabolism Thromboembolism / metabolism, radionuclide imaging* Thrombosis / metabolism, radionuclide imaging Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Colloids; 7440-26-8/Technetium; 7704-34-9/Sulfur; 9001-31-4/Fibrin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exercise thallium imaging: location of perfusion abnormalities in single-vessel coronary disease.
Next Document: Pure follicular thyroid carcinoma: impact of therapy in 214 patients.