Document Detail

Experimental dry socket: microscopic and molecular evaluation of two treatment modalities.
MedLine Citation:
PMID:  21952659     Owner:  NLM     Status:  Publisher    
PURPOSE: To evaluate two treatment modalities of dry socket in rats and to discuss the first findings of the molecular analysis in this experimental model. METHODS: 84 rats underwent a tooth extraction were divided in 4 groups: I-uninfected socket (control), II-infected socket without any treatment, III-infected socket treated with irrigation of 2% sodium iodide and 3% hydrogen peroxide solution, IV-infected socket submitted to curettage, irrigation with physiological saline solution and fulfilled with metronidazole paste as base. The groups were subdivided in postoperative sacrifice periods: 6/15/28 days. A quantitative and a qualitative microscopic analysis was performed. Also, a quantitative analysis was performed using a RealTimePCR to evaluate the genes expression in the wound healing: Collagen Type I/COL-I, vascular endothelial growth factor/VEGF, osteocalcin/OCN, alkaline phosphatase/ALP, runt-related transcription factor 2/RUNX2 and tumor necrosis factor alpha/TNF-α. RESULTS: The group I showed higher bone formation, followed by groups IV, III, II respectively. The group II presented higher inflammatory infiltrate and the wound healing was delayed compared with other groups. It was obtained a significant positive correlation between bone neoformation and the expression of OCN and RUNX2, inflammatory infiltrate with TNF-α and a negative correlation between bone neoformation and TNF-α. CONCLUSION: No significant difference was found between the treatments.
Camila Lopes Cardoso; Osny Ferreira Júnior; Paulo S Perri de Carvalho; Thiago José Dionísio; Tânia Mary Cestari; Gustavo Pompermaier Garlet
Related Documents :
20713489 - Incomplete removal of great saphenous vein is the most common cause for recurrent varic...
21573899 - Effectiveness of a drain in surgical treatment of sacrococcygeal pilonidal disease. res...
12022989 - Development of achalasia secondary to laparoscopic nissen fundoplication.
12797429 - Endoscopic suturing for gastroesophageal reflux disease: clinical outcome with the bard...
3669169 - Ipsilateral ureteroureterostomy and pyeloureterostomy: a review of 15 years of experien...
20488469 - The swedish reflux trial in children: ii. vesicoureteral reflux outcome.
17089089 - Long-term outcome of ten children with opsoclonus-myoclonus syndrome.
2744159 - Late carotid restenosis: aetiologic factors for recurrent carotid artery stenosis durin...
23348639 - Ingestion of glutamine and maltodextrin two hours preoperatively improves insulin sensi...
Publication Detail:
Type:  -    
Journal Detail:
Title:  Acta cirurgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia     Volume:  26     ISSN:  1678-2674     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9103983     Medline TA:  Acta Cir Bras     Country:  -    
Other Details:
Languages:  ENG     Pagination:  365-372     Citation Subset:  -    
Department of Oral Surgery, Bauru School of Dentistry, USP, Bauru, SP, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Morphological findings in the tracheal epithelium of dogs exposed to the inhalation of poorly condit...
Next Document:  Healing activity of laser InGaAlP (660nm) in rats.