Document Detail

Experimental diabetes modulates collagen remodelling of joints in rats.
MedLine Citation:
PMID:  23018246     Owner:  NLM     Status:  MEDLINE    
RESULTS: Higher blood glucose levels and plasma anti-carboxymethyllysine were observed in DG rats when compared to those in CG rats. The final weight was significantly lower in the DG rats than in the CG rats. Histomorphometric evaluation depicted a small quantity of collagen fibers in ligaments and articular cartilage in DG rats, as well as increased collagen in synovial tissue. There was a decrease in cartilage proteoglycans in DG rats when compared with CG rats. Immunofluorescence staining revealed an increase of collagen III and V in ligaments, collagen XI in cartilage, and collagen I in synovial tissue of DG rats compared with CG rats.
CONCLUSION: The ligaments, cartilage and synovia are highly affected following STZ-induced diabetes in rats, due the remodeling of collagen types in these tissues. This process may promote the degradation of the extracellular matrix, thus compromising joint function. Our data may help to better understand the pathogenesis of joint involvement related to diabetes.
Sandra A Atayde; Natalino H Yoshinari; Dafne P Nascimento; Sérgio Catanozi; Priscila C Andrade; Ana Paula P Velosa; Edwin R Parra; Marisa Passarelli; Edna R Nakandakare; Vera L Capelozzi; Walcy R Teodoro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Histology and histopathology     Volume:  27     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-03-14     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  1471-9     Citation Subset:  IM    
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MeSH Terms
Cartilage, Articular / metabolism,  pathology*
Collagen / metabolism*
Diabetes Mellitus, Experimental / metabolism,  pathology*
Extracellular Matrix / metabolism,  pathology
Knee Joint / metabolism,  pathology*
Ligaments / metabolism,  pathology
Rats, Wistar
Synovial Membrane / metabolism,  pathology
Reg. No./Substance:

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