Document Detail

Experimental development of bisphosphonate-related osteonecrosis of the jaws in rodents.
MedLine Citation:
PMID:  23317355     Owner:  NLM     Status:  MEDLINE    
Osteonecrosis of the jaw (ONJ) following the use of bisphosphonates has become of increased interest in the scientific community, due in particular to its as-yet-unsolved pathogenesis. An experimental model of ONJ was induced in normal male rats [alendronate (ALN); 1 mg/Kg/day; n = 10] and matched controls (saline solution; n = 10). After 60 days of drug treatment, all animals were subjected to extractions of the left first lower molars and were euthanized at 3 and 28 days postsurgery. The following analyses were performed: (i) descriptive and quantitative (scores) histological evaluation, (ii) stereometry of distal sockets and (iii) biochemical measurement of C-telopeptide cross-linked collagen type I (CTX) and bone-specific alkaline phosphatase (BALP). The results showed that 28 days postsurgery the animals treated with ALN had areas of exposed and necrotic bone, associated with significant infection, especially in the interalveolar septum area and crestal regions, compared with controls. The levels of CTX, BALP and bone volume, as well as the degrees of inflammation and vascularization, were significantly reduced in these animals. Therefore, analysis of the data presented suggests that ALN therapy is associated with the development of osteonecrosis in the jaws of rodents after tooth extraction.
Nicolau Conte Neto; Luis C Spolidorio; Cleverton R Andrade; Alliny S Bastos; Morgana Guimarães; Elcio Marcantonio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of experimental pathology     Volume:  94     ISSN:  1365-2613     ISO Abbreviation:  Int J Exp Pathol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-05     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9014042     Medline TA:  Int J Exp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. International Journal of Experimental Pathology © 2012 International Journal of Experimental Pathology.
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MeSH Terms
Alkaline Phosphatase / metabolism
Biological Markers / metabolism
Bisphosphonate-Associated Osteonecrosis of the Jaw / etiology,  metabolism,  pathology*
Bone Remodeling
Collagen Type I / metabolism
Disease Models, Animal
Jaw / metabolism,  pathology*,  surgery
Molar / surgery
Peptides / metabolism
Time Factors
Tooth Extraction / adverse effects
Weight Gain
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; EC Phosphatase; X1J18R4W8P/Alendronate

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