Document Detail

Experimental determination of time of intracranial hemorrhage by spectrophotometric analysis of cerebrospinal fluid.
MedLine Citation:
PMID:  7175468     Owner:  NLM     Status:  MEDLINE    
A method for determining the time elapsed after a cerebrovascular accident by examination of the cerebrospinal fluid (CSF) is described. Hemorrhagic intracranial trauma was simulated in dogs by injecting blood into the subarachnoid space. Daily samples of cerebrospinal fluid were gathered during the subsequent 14 days, and the concentrations of oxyhemoglobin and bilirubin were measured using spectrophotometric methods. The hemoglobin coefficient (HC), defined as the ratio of the oxyhemoglobin concentration to the sum of the concentrations of the cerebrospinal fluid pigments, and the hemoglobin-bilirubin index (HBI), the ratio of the oxyhemoglobin and the bilirubin concentrations, are found to permit accurate calculation of the time elapsed after the hemorrhage.
J M Marlet; J de P Barreto Fonseca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of forensic sciences     Volume:  27     ISSN:  0022-1198     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  880-8     Citation Subset:  IM    
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MeSH Terms
Bilirubin / cerebrospinal fluid
Cerebral Hemorrhage / cerebrospinal fluid*
Hemoglobins / cerebrospinal fluid
Time Factors
Reg. No./Substance:
0/Hemoglobins; 635-65-4/Bilirubin

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