Document Detail

Experimental determination of the force required for insertion of a thermoseed into deep brain tissues.
MedLine Citation:
PMID:  2372165     Owner:  NLM     Status:  MEDLINE    
Our laboratories are developing a new technique for delivering localized hyperthermia to deep-seated brain tumors. In this technique, a spherical thermoseed is stereotactically navigated through the brain and tumour tissues via the noncontact application of an external magnetic force. The force required to produce motion of a 3 mm diameter sphere through in vitro brain tissues was measured to be 0.07 +/- 0.03 N. This result was obtained from a series of experiments performed on whole brain specimens extracted from adult canines. Data were also taken with a 3 mm x 3 mm cylinder and a 5 mm sphere. An experimental procedure simulating physiological conditions was developed prior to testing. Evaluations of systematic effects included determinations of the calibration uncertainties, tests of the dependence of the measured force on temperature, and studies of the effects of method of storage of the tissue specimens. The results obtained are compared with (and confirmed by) two different series of experiments performed in vivo on adult canines and with another series of experiments using brain phantom gelatin.
J A Molloy; R C Ritter; M S Grady; M A Howard; E G Quate; G T Gillies
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  18     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-313     Citation Subset:  IM    
Department of Physics, University of Virginia, Charlottesville.
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MeSH Terms
Brain / physiology*
Brain Neoplasms / therapy*
Hyperthermia, Induced / methods*
Prostheses and Implants*

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