Document Detail


Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams.
MedLine Citation:
PMID:  23135315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report presents the first experimental demonstration, to our knowledge, of benchtop polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) for a simultaneous determination of the spatial distribution and amount of gold nanoparticles (GNPs) within small-animal-sized objects. The current benchtop experimental setup successfully produced XFCT images accurately showing the regions containing small amount of GNPs (on the order of 0.1 mg) within a 3 cm diameter plastic phantom. In particular, the performance of the current XFCT setup was improved remarkably (e.g., at least a factor of 3 reduction in XFCT scan time) using a tin-filtered polychromatic beam in comparison with a lead-filtered beam. The results of this study strongly suggest that the current benchtop XFCT configuration can be made practical with a few modifications such as the deployment of array detectors, while meeting realistic constraints on x-ray dose, scan time and image resolution for routine pre-clinical in vivo imaging with GNPs.
Authors:
Bernard L Jones; Nivedh Manohar; Francisco Reynoso; Andrew Karellas; Sang Hyun Cho
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  Physics in medicine and biology     Volume:  57     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-05-03     Revised Date:  2013-12-12    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  N457-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Color
Cone-Beam Computed Tomography / instrumentation*
Gold / chemistry*
Lead / chemistry
Metal Nanoparticles / chemistry*
Phantoms, Imaging
Tin / chemistry*
Grant Support
ID/Acronym/Agency:
R01 CA155446/CA/NCI NIH HHS; R01CA155446/CA/NCI NIH HHS; R21 CA134128/CA/NCI NIH HHS; R21CA134128/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
2P299V784P/Lead; 7440-31-5/Tin; 7440-57-5/Gold
Comments/Corrections

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