Document Detail

Experimental congenital obstructive uropathy.
MedLine Citation:
PMID:  2186545     Owner:  NLM     Status:  MEDLINE    
Continued experimental work in congenital obstructive uropathy is essential to support the rapidly advancing field of fetal medicine. It is possible to reproduce the clinically relevant obstructive lesions in an experimental model. On the basis of data from these models, the tentative conclusion is that in utero intervention is beneficial in severe congenital obstructive uropathy associated with oligohydramnios. The limited human experience provides insufficient data to confirm this hypothesis but has demonstrated the technical feasibility of prenatal interventions. There is a critical need for further refinement in understanding the complex pathophysiology of congenital obstructive uropathy, not only the renal consequences, but also the pulmonary and systemic effects. There remains the particular need to resolve the determinants and indicators of functional salvageability of the kidneys and lungs in congenital obstructive uropathy.
C A Peters; J Mandell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Urologic clinics of North America     Volume:  17     ISSN:  0094-0143     ISO Abbreviation:  Urol. Clin. North Am.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-13     Completed Date:  1990-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0423221     Medline TA:  Urol Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  437-47     Citation Subset:  AIM; IM    
Department of Surgery, Children's Hospital, Boston, Massachusetts.
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MeSH Terms
Disease Models, Animal*
Fetal Diseases / etiology,  pathology,  physiopathology
Ureteral Obstruction / congenital*,  pathology,  physiopathology
Urethra / abnormalities
Urinary Bladder Neck Obstruction / congenital*,  pathology,  physiopathology

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