Document Detail

Experimental congenital hydrocephalus. A review with special consideration of hydrocephalus produced by zinc deficiency.
MedLine Citation:
PMID:  1022424     Owner:  NLM     Status:  MEDLINE    
A review was made of experimental methods available to produce congenital hydrocephalus by teratogenic methods. Radiation, infections, trypan blue, hypervitaminosis A, salicylates and nutritional deficiencies were considered. In the course of prenatal zinc deficiency experiments, congenital hydrocephalus was frequently encountered and histologic sections were made of many representative specimens. Details of the findings are described, among them various types of aqueduct stenosis or obileration. Although these anomalies suggest that occlusion of the aqueduct is the cause of the enlargement of the ventricular system it was noted that there was also ventricular dilatation caudal to the stenotic point of the aqueduct. Hydrocephalus without aqueductal stenosis has also been observed in experimental animals. It seems possible that some cases of congenital hydrocephalus attributed to aqueductal stenosis are examples of hydrocephalus with secondary block of the aqueduct.
A Adeloye; J Warkany
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Child's brain     Volume:  2     ISSN:  0302-2803     ISO Abbreviation:  Childs Brain     Publication Date:  1976  
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7505428     Medline TA:  Childs Brain     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  325-60     Citation Subset:  IM    
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MeSH Terms
Brain / embryology
Copper / deficiency
Disease Models, Animal*
Folic Acid Deficiency / complications
Hydrocephalus* / embryology,  etiology
Hypervitaminosis A
Nicotinic Acids / deficiency
Pregnancy Complications
Riboflavin Deficiency / complications
Time Factors
Trypan Blue
Virus Diseases / complications
Vitamin B 12 Deficiency / complications
Vitamin E Deficiency / complications
Zinc / deficiency*
Reg. No./Substance:
0/Nicotinic Acids; 72-57-1/Trypan Blue; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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