Document Detail

Experimental comparison of the effects of locally administered zoledronic acid and alendronate on the rate of mandibular distraction osteogenesis in dogs.
MedLine Citation:
PMID:  23265985     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The objective of this study was the evaluation of effects of locally administered zoledronic acid and alendronate on rate of osteogenesis in distracted mandible of dogs. STUDY DESIGN: Following mandibular corticotomy, bone segments were maintained in a neutral position by distractor for 7 days then distraction was initiated at a rate of 0.5 mm twice a day for 10 days to achieve a total distraction of 10 mm, followed by a consolidation period. Animals were divided into 3 equal groups according to the injected drug (saline solution [control], zoledronic acid, alendronate). The dogs were killed 2, 6, and 10 weeks following distraction and samples were collected for radiographic examination, assessment of bone mineral density, and histopathological evaluation. RESULTS: Radiographs and histopathological results pointed out that bone formation and maturation of experimental groups were faster than those of the control group. CONCLUSIONS: Local administration of zoledronic acid and alendronate proved to be effective in shortening the consolidation period.
Abdel Aziz Baiomy; Mohamed A Nassan; Elsaeed M Abdellatif; Ashraf Abdel Fattah; Ahmed A H El-Fekey; Abdel Bassit M Abdel Aal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-19
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  -     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Lecturer, Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Assiut), Al-Azhar University, Egypt.
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