Document Detail


Experimental and clinical characteristics in myelodysplastic syndrome patients with or without HLA-DR15 allele.
MedLine Citation:
PMID:  19593744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of the presence of the HLA-DR15 allele on the experimental and clinical features of myelodysplastic syndrome (MDS) by assessing the clinical data of 136 patients with MDS. We observed that the frequency of HLA-DR15 expression in MDS patients (38.7%) was significantly higher than that in the healthy controls (p < 0.01). We noted the following observations with regard to disease progression: None of the 46 HLA-DR15 positive patients with international prognostic scoring system (IPSS) scores <or=1 developed acute myeloid leukaemia (AML) during the follow-up period, while six of the 63 DR15-negative patients with the same IPSS score developed AML within a shorter follow-up period (p = 0.039). Furthermore, the incidence of poor chromosomal abnormalities, the percentage of patients with IPSS scores >or=1.5 and the presence of >or=5% blasts in the bone marrow in the DR15-positive patients were lower than the corresponding findings in the DR15-negative patients. In addition, we also recorded the following observations with regard to bone marrow (BM) failure: The bicytopenia/pancytopenia ratio in the DR15-positive patients was higher than that in the DR15-negative patients (92.4 vs. 78.3%; p = 0.029). The peripheral-neutrophil count and the platelet count in the DR15-positive patients were lower than those in the DR15-negative patients (p = 0.028 and p = 0.011, respectively). Moreover, hypocellularity was more easily detectable in the DR15-positive patients (26.4 vs. 16.9%). In addition, the BM CD4+ lymphocyte count and the CD4/CD8 ratio in the DR15-positive patients were higher than the corresponding values in the DR15-negative patients (p < 0.05 for both). However, there were no significant differences between the polarization of T-helper (T(h)) and T-cytotoxic (T(c)) cells and the cytokine levels in these two patient groups. We concluded that the presence of the HLA-DR15 allele is indicative of a genetic susceptibility to MDS and, the presence of the HLA-DR15 allele showed less association with disease progression and greater association with BM failure.
Authors:
Li Xiao; Liao Qiong; Zhang Yan; Zhang Zheng; Song Luxi; Xu Li; Tao Ying; Liu Yizhi; Pu Quan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hematological oncology     Volume:  28     ISSN:  1099-1069     ISO Abbreviation:  Hematol Oncol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-07     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307268     Medline TA:  Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Copyright Information:
(c) 2009 John Wiley & Sons, Ltd.
Affiliation:
Department of Hematology, Sixth Hospital affiliated to Shanghai Jiaotong University, Shanghai, China. lixiao3326@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Alleles
Asian Continental Ancestry Group / genetics
Bone Marrow / chemistry,  pathology
CD4 Lymphocyte Count
CD4-CD8 Ratio
Disease Progression
Gene Frequency
Genes, MHC Class II*
Genetic Predisposition to Disease
HLA-DR Antigens / genetics*
Humans
Interferon-gamma / analysis
Myelodysplastic Syndromes / blood,  genetics,  immunology*,  pathology
Tumor Necrosis Factor-alpha / analysis
Chemical
Reg. No./Substance:
0/HLA-DR Antigens; 0/HLA-DR15; 0/Tumor Necrosis Factor-alpha; 82115-62-6/Interferon-gamma

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