Document Detail


Experimental arteriosclerosis in Rhesus monkeys induced by multiple risk factors: cholesterol, vitamin D, and nictotine.
MedLine Citation:
PMID:  114963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-four rhesus monkeys were given various regimens involving three vasotoxic factors: dietary hypercholesteremia, hypervitaminosis D2 and nicotinism for period ranging from 14 to 62 weeks. When administered singly, no or only early disease was observed. The combined three "risk factor" group demonstrated the most impressive arteriosclerosis. Major arteriosclerotic changes: fat, calcium and mensenchyme of thirty standardized segments of aorta, coronary and limb arteries of all monkeys were graded according to a standardized system. Statistical analysis revealed that the total arteriosclerotic scores of the three vasotoxic factor group was significantly greater than those of any other group and that this was the only group with significant coronary arteriosclerosis as well as complicated lesions such as thrombosis or occlusion of arterial luminae of the extremities. A lowering of the vitamin D2 dosage, resulting in a lengthening of the survival time of animals which should allow sufficient time for complicated disease to develop, is recommended for future studies.
Authors:
L B Liu; C B Taylor; S K Peng; B Mikkelson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paroi artérielle     Volume:  5     ISSN:  0398-7655     ISO Abbreviation:  Paroi Arterielle     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-12-27     Completed Date:  1979-12-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7606268     Medline TA:  Paroi Arterielle     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  25-37     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriosclerosis / etiology*
Calcinosis
Cholesterol*
Haplorhini
Hypercholesterolemia / etiology
Kidney / pathology
Liver / pathology
Lung / pathology
Macaca mulatta
Nicotine*
Risk
Vitamin D* / administration & dosage
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; 54-11-5/Nicotine; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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