| Experimental antithrombotic effects of sesame seed whole grains and extracts. | |
| | |
MedLine Citation:
|
PMID: 21577091 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Prevention of arterial thrombotic diseases has a high priority in developed countries. An inappropriate diet is known to enhance the risks for acute thrombotic events, and nutritional products experimentally shown to be antithrombotic, might contribute beneficial effects. The present study forms part of a series of investigations into the antithrombotic effect of various foods and vegetables. Roasted and crushed whole grains from six varieties of sesame seeds were added to the diet of mice. Antithrombotic activity was measured in the carotid artery in vivo, using a He-Ne laser-induced thrombosis technique after 12 weeks. Col/Chichibu/Maruteru-2/1995 and T016 varieties showed significant antithrombotic activity, whilst 00037803 was prothrombotic. The acute effects of purified ingredients, sesamin, sesamolin and sesamol, given orally or intra-arterially, were also examined after a single dose. The most effective ingredient was sesamol, followed by sesamolin and sesamin. Daily intake of specific antithrombotic sesame whole grains or purified active ingredients might help to prevent atherothrombotic diseases. |
| | |
Authors:
|
Chifumi Kinugasa; Aki Naemura; Kanae Hyodo; Yoshiki Nakai; Masumi Katsuta; Junichiro Yamamoto |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-16 |
Journal Detail:
|
Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: - ISSN: 1473-5733 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
aLaboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe, Japan bDevelopment Department, Kuki Industry Company Ltd, Yokkaichi, Japan cResearch Collaboration and Council Secretariat, The Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Causes of Short-term Mortality After Appendectomy: A Population-Based Case Control Study.
Next Document: Bronchoscopic intratumoral injection of tranexamic acid: a new technique for control of biopsy-induc...