| Experimental animal models of pancreatic cancer (review). | |
| | |
MedLine Citation:
|
PMID: 10891528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pancreatic adenocarcinoma is currently the fifth leading cause of cancer-related death in the United States and is largely refractory to conventional therapies. The average survival from diagnosis to death is 4-6 months. The major cause of death is rapid development of metastasis involving the lymph nodes, liver, lungs, or peritoneum. To understand its etiology and eventually to make prevention possible and effective, appropriate carcinogenesis models will certainly help shed more light on the process of pancreatic carcinogenesis and help us understand the effects of environmental and genetic elements on pancreatic cancer development. The development of new treatment strategies to control cancer metastasis is of immediate urgency. Fulfillment of this difficult task relies on our knowledge of the cellular and molecular biology of pancreatic cancer metastasis, and the use of relevant animal models will certainly help define each aspect of this complicated process. |
| | |
Authors:
|
Q Shi; K Xie |
Related Documents
:
|
12170018 - Evidence-based pancreatic head resection for pancreatic cancer and chronic pancreatitis. 16930338 - Pancreatic cancer initially presenting with a pseudocyst at the splenic flexure. 20711688 - A 67-year-old woman with brca 1 mutation associated with pancreatic adenocarcinoma. 21656578 - Effects of mdm2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at... 21271578 - Synchronous second primary tumors in 2,016 head and neck cancer patients: role of sympt... 15298598 - Helicobacter pylori infection in two areas in japan with different risks for gastric ca... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: International journal of oncology Volume: 17 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 2000 Aug |
Date Detail:
|
Created Date: 2000-08-29 Completed Date: 2000-08-29 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: GREECE |
Other Details:
|
Languages: eng Pagination: 217-25 Citation Subset: IM |
Affiliation:
|
Departments of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
secondary,
therapy Animals Disease Models, Animal* Humans Neoplasm Transplantation Pancreatic Neoplasms / pathology, therapy* Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
|
CA16672/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Indications for computed tomography in patients with minor head injury.
Next Document: Theophylline and cisplatin synergize in down regulation of BCL-2 induction of apoptosis in human gra...