Document Detail


Experimental angioplasty: lessons from the laboratory.
MedLine Citation:
PMID:  6160743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To elucidate the pathophysiologic mechanisms of transluminal angioplasty, normal coronary arteries in dogs, atherosclerotic human coronary arteries, and atherosclerotic vessels in rabbits were studied after angioplasty. Normal canine coronary arteries showed desquamation of endothelium, exposure of subendothelial connective tissue elements, and deposition of a carpet of platelets, fibrin, and occasional red blood cells. Administration of low molecular weight dextran before angioplasty decreased platelet deposition. Atherosclerotic human coronary arteries studied postmortem showed enlargement of lumen size after angioplasty due to splitting and disruption of the plaque and the underlying media. Endothelial desquamation and splitting of the plaque were also seen in atherosclerotic vessels in rabbits after angioplasty. The amount of splitting seems to depend on the relative size of the stenotic vessel and the inflated angioplasty balloon. Animals studied sequentially showed retraction of the separated intimal plaque elements and further lumen enlargement after 1-2 weeks. Two mechanisms of successful angioplasty are suggested by these studies: (1) desquamation of superficial plaque elements and (2) splitting of the plaque with retraction of intimal flaps as healing occurs. These mechanisms have important implications for the treatment of patients undergoing percutaneous transluminal angioplasty.
Authors:
P C Block; J T Fallon; D Elmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  135     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-02-24     Completed Date:  1981-02-24     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  907-12     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / pathology*
Aortography
Arteriosclerosis / pathology,  radiography,  therapy*
Catheterization / methods*
Coronary Vessels / pathology*
Dextrans / administration & dosage
Dilatation / methods
Disease Models, Animal
Dogs
Endothelium / pathology
Femoral Artery / radiography
Humans
Rabbits
Chemical
Reg. No./Substance:
9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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