| Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. | |
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MedLine Citation:
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PMID: 18166324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of the study was to determine the effects in late gestation of Ureaplasma parvum serovar 3 colonization and the effects, preterm, of U. parvum serovar 6. STUDY DESIGN: Ewes received an intraamniotic (i.a.) injection of U. parvum serovar 6 (20 x 10(6) colony-forming units [cfu]; n = 9), U. parvum serovar 3 (20 x 10(3) cfu; n = 6), vehicle (n = 10), or saline (n = 4) on day 80 of pregnancy (d). The lambs were delivered at 125 d (U. parvum serovar 6, n = 9; saline or media controls, n = 9) or 145 d (U. parvum serovar 3, n = 6; media controls, n = 5) for assessment of inflammation and lung maturation. RESULTS: I.a. ureaplasmas caused histologic chorioamnionitis but not preterm delivery. Fetal lung epithelium was colonized with ureaplasmas at both gestational ages, and pulmonary interleukin-8 levels had doubled in the ureaplasma-colonized animals, compared with the controls at 145 d. Surfactant levels in bronchoalveolar lavage fluid had increased 8-fold and 2.5-fold at 125 and 145 d, respectively, after ureaplasma injection. CONCLUSION: Fetal lung inflammation and altered development accompanies ureaplasma colonization, regardless of age at delivery. |
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Authors:
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Timothy J M Moss; Christine L Knox; Suhas G Kallapur; Ilias Nitsos; Christina Theodoropoulos; John P Newnham; Machiko Ikegami; Alan H Jobe |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 198 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-01 Completed Date: 2008-01-28 Revised Date: 2011-06-06 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 122.e1-8 Citation Subset: AIM; IM |
Affiliation:
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School of Women's and Infants' Health, Faculty of Medicine, Dentistry, and Health Sciences, University of Western Australia, Perth, Western Australia, Australia. tim.moss@uwa.edu.au |
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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microbiology Animals Animals, Newborn Chorioamnionitis / microbiology, physiopathology* Disease Models, Animal Female Fetal Organ Maturity Pregnancy Pregnancy, Animal* Random Allocation Reference Values Sheep, Domestic Ureaplasma / pathogenicity* Ureaplasma Infections* |
| Grant Support | |
ID/Acronym/Agency:
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HL-65397/HL/NHLBI NIH HHS; R01 HL065397-01/HL/NHLBI NIH HHS; R01 HL065397-02/HL/NHLBI NIH HHS; R01 HL065397-03/HL/NHLBI NIH HHS; R01 HL065397-04/HL/NHLBI NIH HHS; R01 HL065397-05/HL/NHLBI NIH HHS; R01 HL065397-06/HL/NHLBI NIH HHS; R01 HL065397-07/HL/NHLBI NIH HHS; R01 HL065397-08/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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