| Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs. | |
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MedLine Citation:
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PMID: 18204116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allergic rhinitis is one of the most common causes of chronic cough. The characteristic feature of allergic rhinitis is eosinophilic nasal inflammation. This study was determined to find the relation between airway eosinophils and chemically-induced cough in guinea pigs with antigen-induced rhinitis at the early and late allergic phases. Forty animals were sensitized with ovalbumin (OVA) and divided into four separated groups. Four weeks later, the sensitized animals were either once or repeatedly (6 times at 7-day intervals) intranasally challenged with OVA to develop experimental allergic rhinitis. The control group was given saline. Cough was elicited by inhalation of citric acid aerosols and evaluated at 30 min (early phase) or 24 h (late phase) after the 1st or 6th nasal challenge (NC) in the sensitized animals. The citric acid-induced cough was significantly increased in the sensitized animals in the early allergic phase after the first and repeated NC compared with the control values [14(9-19) vs. 16(10-17) vs. 8(6-10); P=0.049], whereas there was no significant increase in the cough response tested in the late allergic phase. A correlation between the cough intensity and the number of eosinophils from nasal mucosa only (P=0.008) was found. |
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Authors:
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M Brozmanova; V Bartos; L Plank; M Tatar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 58 Suppl 5 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 57-65 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. brozmanova@jfmed.uniba.sk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Animals Bronchi / immunology Citric Acid / administration & dosage Cough / chemically induced, immunology* Disease Models, Animal Eosinophilia / complications*, immunology Guinea Pigs Larynx / immunology Lung / immunology Mice Nasal Mucosa / immunology* Ovalbumin / immunology Pulmonary Eosinophilia / complications, immunology Rhinitis, Allergic, Perennial / complications*, immunology Severity of Illness Index Time Factors Trachea / immunology |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 77-92-9/Citric Acid; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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