Document Detail

Experimental allergic encephalomyelitis: a neurourological study.
MedLine Citation:
PMID:  3338519     Owner:  NLM     Status:  MEDLINE    
To assess the neurourological disturbances produced by the perivascular inflammatory process in the acute phase of experimental allergic encephalomyelitis, we carried out a controlled study. Forty-six New Zealand male rabbits were inoculated with an encephalitogenic preparation. Twenty-seven of them developed neurological deficits in an average of 9.3 days postinoculation. A sample of 19 subjects was used as a control. The subjects were studied within 2 days after the manifestation of the first sign of encephalomyelitis. An average of eight successive cystosphincterograms were recorded. Their entire central nervous system was removed intact and suspended in 10% neutral buffered Formalin solution for 2 weeks, then cut into segments, embedded in paraffin, and finally stained with hematoxylin-eosin and Luxol Fast Blue. The results demonstrated a significant reduction of mean vesical capacity, maximum urethral pressure, and mean urethral pressure in the group with encephalomyelitis. Furthermore, we found a significant negative correlation between the average number of cellular perivascular infiltrates in the spinal sacral segment and urethral pressures. The results showed a significant negative correlation between supreamesencephalic inflammation and mean vesical capacity.
L Germain; C Galeano; J Lamarche; M M Elhilali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental neurology     Volume:  99     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-07     Completed Date:  1988-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-46     Citation Subset:  IM    
Department of Physiology, University of Sherbrooke, School of Medicine, Quebec, Canada.
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MeSH Terms
Central Nervous System / pathology*
Encephalomyelitis, Autoimmune, Experimental / pathology*,  physiopathology
Nervous System / physiopathology
Urethra / innervation,  physiopathology*

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