Document Detail

Experimental allergic encephalomyelitis. Early T cells and TG cells are separate subpopulations.
MedLine Citation:
PMID:  6216327     Owner:  NLM     Status:  MEDLINE    
To investigate whether previously described fluctuations in circulating early T cell levels reflected a change in suppressor activity, early T cell and TG cell values were determined in guinea pigs with acute and chronic experimental allergic encephalomyelitis (EAE) and normals. It was found that while both subpopulations showed similar changes in EAE, particularly decreases during periods of clinical worsening, changes in the two subpopulations were not always synchronous. Also, similar levels of TG cells could be found both in isolated early and isolated late (total) T cells. These two lines of evidence indicate that early T cells and TG cells are heterologous populations and that early T cells do not reflect suppressor activity, findings in accord with a similar, recent study on multiple sclerosis.
U Traugott; C S Raine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  56     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental / immunology*,  pathology
Guinea Pigs
T-Lymphocytes / cytology,  immunology*
T-Lymphocytes, Regulatory / immunology
Grant Support

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