Document Detail


Experimental advances in understanding allergic airway inflammation.
MedLine Citation:
PMID:  23277043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asthma is largely an inflammatory disease, with the development of T cell mediated inflammation in the lung following exposure to allergen or other precipitating factors. Currently, the major therapies for this disease are directed either at relief of bronchoconstriction (ie beta-agonists) or are non-specific immunomodulators (ie, corticosteroids). While much attention has been paid to factors that regulate the initiation of an inflammatory response, chronic inflammation may also be due to defects in regulatory mechanisms that limit or terminate immune responses. In this review, we explore the elements controlling both the recruitment of T cells to the lung and their function. Possibilities for future therapeutic intervention are highlighted.
Authors:
Christine M Deppong; Jonathan M Green
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-09-09     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  167-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Asthma / immunology*
Humans
Inflammation / immunology
Respiratory Hypersensitivity / immunology
Grant Support
ID/Acronym/Agency:
R01 HL062683/HL/NHLBI NIH HHS; U19 AI070489/AI/NIAID NIH HHS
Comments/Corrections

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