| Experimental advances in understanding allergic airway inflammation . | |
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MedLine Citation:
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PMID: 23277043 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Asthma is largely an inflammatory disease, with the development of T cell mediated inflammation in the lung following exposure to allergen or other precipitating factors. Currently, the major therapies for this disease are directed either at relief of bronchoconstriction (ie beta-agonists) or are non-specific immunomodulators (ie, corticosteroids). While much attention has been paid to factors that regulate the initiation of an inflammatory response, chronic inflammation may also be due to defects in regulatory mechanisms that limit or terminate immune responses. In this review, we explore the elements controlling both the recruitment of T cells to the lung and their function. Possibilities for future therapeutic intervention are highlighted. |
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Authors:
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Christine M Deppong; Jonathan M Green |
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Publication Detail:
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Type: Journal Article Date: 2013-01-01 |
Journal Detail:
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Title: Frontiers in bioscience (Scholar edition) Volume: 5 ISSN: 1945-0524 ISO Abbreviation: Front Biosci (Schol Ed) Publication Date: 2013 |
Date Detail:
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Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485241 Medline TA: Front Biosci (Schol Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 167-80 Citation Subset: IM |
Affiliation:
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Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Box 8052 CSRB, 660 S. Euclid Avenue, St. Louis, MO 63110. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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