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Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis.
MedLine Citation:
PMID:  21895968     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We used rat experimental myocardial infarction to study the ultrastructural recovery, especially neo-angiogenesis in the infarction border zone. We were interested in the possible role(s) of telocytes (TCs), a novel type of interstitial cell very recently discovered in myocardim (see www.telocytes.com). Indeed, electron microscopy, immunocytochemistry, and analyses of several proangiogenic microRNAs provided evidence for TC involvement in neo-angiogenesis after myocardial infarction. Electron microscopy showed the close spatial association of TCs with neoangiogenetic elements. Higher resolution provided the following information: a) the intercellular space between the abluminal face of endothelium and its surrounding TCs is frequently less than 50 nm; b) TCs establish multiple direct nanocontacts with endothelial cells, where the extracellular space seems obliterated; such nanocontacts have a length of 0.4-1.5 μm; c) the absence of basal membrane on the abluminal face of endothelial cell. Besides the physical contacts (either nanoscopic or microscopic) TCs presumably contribute to neo-angiognesis via paracrine secretion (as shown by immunocytochemistry for VEGF or NOS2). Last but not least, TCs contain measurable quantities of angiogenic microRNAs (e.g. let-7e, 10a, 21, 27b, 100, 126-3p, 130a, 143, 155). Taken together, the direct (physical) contact of TCs and endothelial cells, as well as the indirect (chemical) influence in 'angiogenic zones', suggest an important participation of TCs in neo-angiogenesis during the late stage of myocardial infarction.
Authors:
C G Manole; V Cismasiu; Mihaela Gherghiceanu; L M Popescu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-6
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  -     ISSN:  1582-4934     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
Affiliation:
Department of Cellular and Molecular Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania Division of Advanced Studies, 'Victor Babeș' National Institute of Pathology, Bucharest, Romania National Academy of Sciences, Bucharest, Romania.
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