| Experimental Yersinia enterocolitica enteritis in rabbits. | |
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MedLine Citation:
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PMID: 7380565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Young rabbits weighing 500 to 800 g were inoculated orogastrically with clinical isolates of Yersinia enterocolitica (serotype O:3; enterotoxigenic; HeLa cell invasive) at a dose of 1.4 X 10(10) bacteria suspended in 10% sodium bicarbonate solution. Diarrhea developed in 41 (87%) of 47 rabbits, with a mean +/- standard deviation onset at 5.4 +/- 2.4 days. The attack rate and onset of diarrhea were correlated with inoculum size. The 50% infectious dose was 2.9 X 10(8) bacteria. Bacterial colonization occurred in almost all rabbits, regardless of inoculum size. Seroconversion was demonstrated in 30 (71%) of 42 rabbits with or without diarrhea. Histopathological alterations were present in the jejuna, ilea, and colons of rabbits with diarrhea; the most pronounced changes were generally noted in the ilea. Crypt abscesses localized at the depth of the intestinal glands were observed consistently and were composed of a bacterial nidus admixed with and enveloped by inflammatory cells comprised of eosinophils, neutrophils, and mononuclear cells. Rabbits inoculated with a raw fish isolate of Y. enterocolitica (serotype O:6,30; non-enterotoxigenic; HeLa cell noninvasive) did not exhibit infection clinically, bacteriologically, or pathologically. |
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Authors:
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C H Pai; V Mors; T A Seemayer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infection and immunity Volume: 28 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1980 Apr |
Date Detail:
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Created Date: 1980-08-28 Completed Date: 1980-08-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 238-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Bacterial / analysis Diarrhea / microbiology*, pathology Disease Models, Animal* Enterotoxins / analysis Inflammation Intestines / pathology Rabbits Yersinia / growth & development*, immunology Yersinia Infections / immunology, microbiology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Enterotoxins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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