Document Detail

Experimental Yersinia enterocolitica enteritis in rabbits.
MedLine Citation:
PMID:  7380565     Owner:  NLM     Status:  MEDLINE    
Young rabbits weighing 500 to 800 g were inoculated orogastrically with clinical isolates of Yersinia enterocolitica (serotype O:3; enterotoxigenic; HeLa cell invasive) at a dose of 1.4 X 10(10) bacteria suspended in 10% sodium bicarbonate solution. Diarrhea developed in 41 (87%) of 47 rabbits, with a mean +/- standard deviation onset at 5.4 +/- 2.4 days. The attack rate and onset of diarrhea were correlated with inoculum size. The 50% infectious dose was 2.9 X 10(8) bacteria. Bacterial colonization occurred in almost all rabbits, regardless of inoculum size. Seroconversion was demonstrated in 30 (71%) of 42 rabbits with or without diarrhea. Histopathological alterations were present in the jejuna, ilea, and colons of rabbits with diarrhea; the most pronounced changes were generally noted in the ilea. Crypt abscesses localized at the depth of the intestinal glands were observed consistently and were composed of a bacterial nidus admixed with and enveloped by inflammatory cells comprised of eosinophils, neutrophils, and mononuclear cells. Rabbits inoculated with a raw fish isolate of Y. enterocolitica (serotype O:6,30; non-enterotoxigenic; HeLa cell noninvasive) did not exhibit infection clinically, bacteriologically, or pathologically.
C H Pai; V Mors; T A Seemayer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  28     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  238-44     Citation Subset:  IM    
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MeSH Terms
Antibodies, Bacterial / analysis
Diarrhea / microbiology*,  pathology
Disease Models, Animal*
Enterotoxins / analysis
Intestines / pathology
Yersinia / growth & development*,  immunology
Yersinia Infections / immunology,  microbiology*,  pathology
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Enterotoxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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