Document Detail


Experimental Coxiella burnetii infection in pregnant goats: a histopathological and immunohistochemical study.
MedLine Citation:
PMID:  16997003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnant goats were inoculated subcutaneosly with Coxiella burnetii and the course of infection was studied. Abortion in the last third of pregnancy occurred in all infected animals. Tissues from the placenta and other organs were studied before and after abortion by immunohistochemistry and PCR analysis. After infection, mild lesions were observed in several maternal organs, mainly the mammary gland but also the lung and the liver. The trophoblast cells of the choriallantoic membrane were the first target cells of the placenta; there was, however, a substantial delay between initial infection and placental colonization. In the last weeks of pregnancy, just before abortion, massive bacterial multiplication was detected in the placenta. In this stage of infection a necrotic and suppurative placentitis separated the fetal trophoblast cells from maternal syncytial epithelium. Vasculitis was observed in the fetal mesenchyme. A strong maternal T-cell response was detected in the inter-placentomal areas but not in the placentomes, where only neutrophils and smaller numbers of macrophages were associated with the lesions. Neither lesions nor C. burnetii DNA were found in maternal organs in animals maintained until day 120 post-abortion.
Authors:
J Sánchez; A Souriau; A J Buendía; N Arricau-Bouvery; C M Martínez; J Salinas; A Rodolakis; J A Navarro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  135     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:    2006 Aug-Oct
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-12-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  108-15     Citation Subset:  IM    
Affiliation:
Departamento de Anatomía y Anatomía Patológica Comparadas, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain. jsanchez@um.es
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MeSH Terms
Descriptor/Qualifier:
Aborted Fetus / immunology,  microbiology,  pathology
Abortion, Induced / veterinary
Animals
Antigens, Bacterial / metabolism
Chorioallantoic Membrane / pathology
Coxiella burnetii / pathogenicity*
Female
Goat Diseases / immunology,  microbiology,  pathology*
Goats / microbiology*
Infectious Disease Transmission, Vertical
Liver / immunology,  microbiology,  pathology
Lung / immunology,  microbiology,  pathology
Mammary Glands, Animal / immunology,  microbiology,  pathology
Placenta / microbiology,  pathology
Pregnancy
Q Fever / pathology,  veterinary*
T-Lymphocytes / immunology,  pathology
Vasculitis / microbiology,  veterinary
Chemical
Reg. No./Substance:
0/Antigens, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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