Document Detail


Experimental Borrelia burgdorferi infection in Peromyscus leucopus.
MedLine Citation:
PMID:  8028098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the susceptibility of laboratory-reared adult and infant white-footed mice (Peromyscus leucopus) to a known pathogenic isolate of Borrelia burgdorferi (N40). Two-month-old and 3-day-old Peromyscus were inoculated intradermally with 10(6) to 10(7) spirochetes. At 21 days for adults or 30 days for infants post inoculation, mice were killed, and tissues were cultured for spirochetes and examined microscopically. Based on serology and culture, adult mice became infected but did not have any gross or microscopic lesions. Mice inoculated as infants became infected, and also developed carditis and multifocal arthritis. Contact transmission between inoculated infants and their naive mothers was not observed. Age at inoculation appeared to be a critical factor in inducing Lyme borreliosis lesions in Peromyscus leucopus, as in other species.
Authors:
K D Moody; G A Terwilliger; G M Hansen; S W Barthold
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of wildlife diseases     Volume:  30     ISSN:  0090-3558     ISO Abbreviation:  J. Wildl. Dis.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-08     Completed Date:  1994-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0244160     Medline TA:  J Wildl Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-61     Citation Subset:  IM    
Affiliation:
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520.
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MeSH Terms
Descriptor/Qualifier:
Animals
Borrelia burgdorferi Group / isolation & purification,  pathogenicity*
Disease Susceptibility
Female
Lyme Disease / microbiology,  pathology,  veterinary*
Male
Peromyscus / microbiology*
Rodent Diseases / microbiology*,  pathology
Grant Support
ID/Acronym/Agency:
AI 26815/AI/NIAID NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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