| Experimental Borrelia burgdorferi infection in Peromyscus leucopus. | |
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MedLine Citation:
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PMID: 8028098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the susceptibility of laboratory-reared adult and infant white-footed mice (Peromyscus leucopus) to a known pathogenic isolate of Borrelia burgdorferi (N40). Two-month-old and 3-day-old Peromyscus were inoculated intradermally with 10(6) to 10(7) spirochetes. At 21 days for adults or 30 days for infants post inoculation, mice were killed, and tissues were cultured for spirochetes and examined microscopically. Based on serology and culture, adult mice became infected but did not have any gross or microscopic lesions. Mice inoculated as infants became infected, and also developed carditis and multifocal arthritis. Contact transmission between inoculated infants and their naive mothers was not observed. Age at inoculation appeared to be a critical factor in inducing Lyme borreliosis lesions in Peromyscus leucopus, as in other species. |
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Authors:
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K D Moody; G A Terwilliger; G M Hansen; S W Barthold |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of wildlife diseases Volume: 30 ISSN: 0090-3558 ISO Abbreviation: J. Wildl. Dis. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-08-08 Completed Date: 1994-08-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0244160 Medline TA: J Wildl Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 155-61 Citation Subset: IM |
Affiliation:
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Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Borrelia burgdorferi Group / isolation & purification, pathogenicity* Disease Susceptibility Female Lyme Disease / microbiology, pathology, veterinary* Male Peromyscus / microbiology* Rodent Diseases / microbiology*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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AI 26815/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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