Document Detail

Experimental "chronic" African trypanosomiasis: endocrine dysfunctions generated by parasitic components released during the tryptanolytic phase in rats.
MedLine Citation:
PMID:  8223986     Owner:  NLM     Status:  MEDLINE    
The disorders of the gonadotropic axis have been studied during the course of a "chronic" african trypanosomiasis induced experimentally in rats inoculated by the variant Trypanosoma brucei brucei AnTat 1.1.E. The levels of serum and pituitary LH as well as serum testosterone and corticosterone have been determined, during the infestation, at a particular period of the circadian cycle, in regard to the parasitemia variations. In addition, the inoculation of trypanosomal component fractions [obtained by concanavalin-A sepharose chromatography (conA-components)], has been performed in an attempt to define more exactly the nature of factor(s) producing the hypotestosteronemia in rats. This work evidenced that the hormonal parameter levels were predominantly decreased at the trypanolytic phase during the evolution of the disease. The action towards the hypothalamo-pituitary gonadal axis was attributed not only to peculiar trypanosomal enzyme(s) [a serine, thiol-dependent, cation sensitive endoprotease with a post-proline cleaving activity (purified from unretained conA fraction)], but also to protein and/or glycoprotein factor(s) released by the trypanosomes (components with affinity to the lectin).
B Soudan; D Tetaert; M Hublart; A Racadot; D Croix; A Boersma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and clinical endocrinology     Volume:  101     ISSN:  0232-7384     ISO Abbreviation:  Exp. Clin. Endocrinol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-20     Completed Date:  1993-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302802     Medline TA:  Exp Clin Endocrinol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  166-72     Citation Subset:  IM    
Unité INSERM n. 16, CHR, Lille, France.
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MeSH Terms
Chronic Disease
Circadian Rhythm / physiology
Corticosterone / blood
Endocrine System Diseases / blood,  parasitology*,  physiopathology*
Iodine Radioisotopes / diagnostic use
Luteinizing Hormone / blood
Rats, Sprague-Dawley
Testosterone / blood
Trypanosoma brucei brucei / growth & development*
Trypanosomiasis, African / blood,  parasitology*,  physiopathology*
Reg. No./Substance:
0/Iodine Radioisotopes; 50-22-6/Corticosterone; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone

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