| Experiment and computer-aided simulation: complementary tools to understand exercise metabolism. | |
| | |
MedLine Citation:
|
PMID: 14641039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During the last two decades the concept of the MLSS (maximal lactate steady state) has been established. The MLSS detects the highest level of the BLC (blood lactate concentration) and the corresponding workload (MLSS workload) that can be maintained over time without continual BLC accumulation. In spite of a lack of experimental and/or theoretical foundation, it has been speculated that the level of the MLSS may decrease with increasing performance capacity. The potential inter-relationship between performance capacity and BLC response to prolonged constant workload will be analysed based on a recent study, which provided evidence that the MLSS is independent of performance whereas MLSS workload increases with performance capacity, and by a computer-aided simulation. The simulated model modifies and combines previous theories put forward to explain the response of BLC to exercise and incorporates a theory about limiting factors of oxygen transport to the muscle cell. Simulations consider the BLC response to selected prolonged constant workloads while paying special respect to changes in body structure and substrate utilization, which are generally accepted as limiting factors of performance capacity. This complex modulation of appearance and disappearance of lactate during constant prolonged exercise seems to support the experimental results, which indicated independence between MLSS and performance capacity. |
| | |
Authors:
|
R Beneke |
Related Documents
:
|
15308499 - Biochemistry of exercise-induced metabolic acidosis. 15531559 - Monocarboxylate transporters, blood lactate removal after supramaximal exercise, and fa... 8444249 - Oxygen deficit and blood lactate in prepubertal boys during exercise above the anaerobi... 4003569 - Energy sources in fully aerobic rest-work transitions: a new role for glycolysis. 2575959 - Aerobic training effects on maximum oxygen consumption, lactate threshold and lactate d... 18379209 - Current trends in lactate metabolism: introduction. 9558019 - Chronic fatigue syndrome: a literature review from a physiatric perspective. 15308499 - Biochemistry of exercise-induced metabolic acidosis. 11712279 - Anomalous origin of the left coronary artery from the pulmonary artery. surgical treatm... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biochemical Society transactions Volume: 31 ISSN: 0300-5127 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2003 Dec |
Date Detail:
|
Created Date: 2003-12-03 Completed Date: 2004-08-17 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
|
Languages: eng Pagination: 1263-6 Citation Subset: IM |
Affiliation:
|
Department of Biological Sciences, Centre for Sports and Exercise Science, Central Campus, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, U.K. rbeneke@essex.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Computer Simulation Energy Metabolism* Exercise* Humans Male |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Retrograde transport of toxins across the endoplasmic reticulum membrane.
Next Document: Nutritional status, metabolic responses to exercise and implications for performance.