| Experiences of photodynamic therapy in dermatology. | |
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MedLine Citation:
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PMID: 9002265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From March 1988 to May 1994, 15 patients underwent the treatment protocol of superficial photodynamic therapy (PDT) in dermatological localized malignancies. Two tumours (one M. Queyrat of the penis, one basalioma) were treated primarily; the other 13 patients experienced relapses of underlying disease after treatment by surgery, radiotherapy or chemotherapy. Most of the patients (10/15) received doses of 2 mg Photosan III kg-1 body weight (BW), four received a lower dose of 1-1.5 mg kg-1 BW and one patient received 3 mg kg-1 BW. Only one remarkable side-effect (tachyarrhythmia) during Photosan III infusion occurred. All patients were treated by an argon dye laser system. The light dose was 200 J cm-2 (11 patients) and 150 J cm-2 (four patients). Complete response occurred in six lesions, including one M. Queyrat and five basaliomas. Two patients had significant partial response with distinct regression of tumour (one pretreated basalioma of the upper lip and one superficially spreading mesothelioma of the scrotum). Five patients (all basaliomas) demonstrated only local response and two patients gave no response (one basalioma, one melanoma metastasis). The results obtained from this small sample suggest the necessity of an optical dosimetric system. At present, PDT should be restricted for selected or pretreated cases. |
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Authors:
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G Koderhold; R Jindra; H Koren; G Alth; G Schenk |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of photochemistry and photobiology. B, Biology Volume: 36 ISSN: 1011-1344 ISO Abbreviation: J. Photochem. Photobiol. B, Biol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-13 Completed Date: 1997-03-13 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 8804966 Medline TA: J Photochem Photobiol B Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 221-3 Citation Subset: IM |
Affiliation:
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Special Department of Radiotherapy, Lainz, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Basal Cell
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drug therapy Dermatology / methods* Eye Neoplasms / drug therapy Hematoporphyrins Humans Male Mesothelioma / drug therapy Penile Neoplasms / drug therapy Photochemotherapy* Photosensitizing Agents / therapeutic use Testicular Neoplasms / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Hematoporphyrins; 0/Photosensitizing Agents; 136219-06-2/photosan III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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