| Experience with the use of cefotaxime in the treatment of bacterial meningitis. | |
| | |
MedLine Citation:
|
PMID: 3513559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Information on 62 bacteriologically confirmed cases of bacterial meningitis treated with cefotaxime in this country was obtained retrospectively from infectious disease consultants. This series of cases differed markedly from the world cumulative case data thus far presented. One of the two most common organisms treated was the pneumococcus (allergy to penicillin or misdiagnosis of the Gram stain results were the major reasons given). The other organism was Klebsiella. Unanticipated bacteriologic successes were noted in two cases of staphylococcal meningitis secondary to parameningeal foci. The bacteriologic cure rate and survival rate were about 85 percent. Failure of monotherapy was seen in one case of Pseudomonas meningitis, as well as in three of five cases of Enterobacter meningitis. In addition, two cases of Escherichia coli meningitis in which moxalactam therapy inexplicably failed were cured with cefotaxime. Close analysis of killing kinetics appeared to explain the Enterobacter and E. coli failures. Thus, overall not all gram-negative species and not all isolates of any particular species that cause meningitis can be successfully treated by cephalosporins. Data obtained during the investigative trials do not appear to be entirely predicative of what occurred during the free clinical use of an antibiotic. Post-investigatory follow-up and surveillance of all newly introduced therapeutic agents are needed. |
| | |
Authors:
|
C E Cherubin; R H Eng |
Related Documents
:
|
11229839 - Reappraisal of lung tap: review of an old method for better etiologic diagnosis of chil... 10337519 - Congenital malformation of the inner ear associated with recurrent meningitis. 12585239 - Spontaneous cerebrospinal fluid otorrhoea: case report and literature review. 20396479 - Aseptic meningitis in kikuchi's disease. 15226859 - Pericarditis caused by beta-lactamase-producing haemophilus influenzae: report of two c... 6401419 - Aspergillosis of the cerebral ventricles in a heroin abuser. case report and review of ... 16857249 - Unilateral cervical cancer in a patient with cervix duplex. 8041399 - Clinical, electrophysiological, and myelographic studies of 9 patients with cervical sp... 22565049 - Management outcomes of facial nerve tumors: comparative outcomes with observation, cybe... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The American journal of medicine Volume: 80 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1986 Mar |
Date Detail:
|
Created Date: 1986-04-14 Completed Date: 1986-04-14 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 398-404 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Bacterial Infections / drug therapy* Cefotaxime / pharmacology, therapeutic use* Escherichia coli / drug effects Escherichia coli Infections / drug therapy Humans Infant, Newborn Klebsiella Infections / drug therapy Male Meningitis / drug therapy*, etiology Meningitis, Pneumococcal / drug therapy Microbial Sensitivity Tests Middle Aged Moxalactam / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
63527-52-6/Cefotaxime; 64952-97-2/Moxalactam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bacteriologic contamination of intravenous infusion delivery systems in an intensive care unit.
Next Document: Effects of aging on the renal glomerulus.