Document Detail

Experience with quinine in falciparum malaria.
MedLine Citation:
PMID:  10695226     Owner:  NLM     Status:  MEDLINE    
During a period of 1 year from July 95 to June 96, 60 patients with falciparum malaria were treated with quinine at Kasturba Medical College Hospital, Mangalore. Of these, 24 patients developed adverse effects to quinine. They were cinchonism (15) cardiotoxicity (10) hypoglycemia (9) hyperventilation (3) hypersensitivity reactions (3) and hypokalemia (1). Cardiotoxicity was noted in 4 of the 7 patients who received intravenous quinine and all four had renal and hepatic failure and prolonged Q-Tc on electrocardiogram. All 4 died of cardiac arrhythmias, 2 had broad QRS tachycardia and 2 had sinus bradycardia. We conclude that: 1. Quinine should be used cautiously in patients with impaired hepatic or renal function and in those with prolonged QTc as it can lead to cardiotoxicity in the form of I0 AV block, prolonged Q-Tc, broad QRS tachycardai or fatal bradyarrhythmia. Dosage reduction to 5 mg/kg body weight in the patients seem to be safer. 2. Hypoglycemia is a very frequent complication of quinine therapy and special care and frequent blood sugar estimations are required especially if the patient has vomiting. 3. Parenteral quinine is more likely to cause toxicity than oral quinine as earlier described.
U K Padmaja; P Adhikari; P Periera
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Indian journal of medical sciences     Volume:  53     ISSN:  0019-5359     ISO Abbreviation:  Indian J Med Sci     Publication Date:  1999 Apr 
Date Detail:
Created Date:  2000-03-16     Completed Date:  2000-03-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0373023     Medline TA:  Indian J Med Sci     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Clinical Pharmacology Unit, KMC Hospital, Attavar, Mangalor.
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MeSH Terms
Administration, Oral
Antimalarials / administration & dosage,  adverse effects*
Dose-Response Relationship, Drug
Drug Resistance
Injections, Intravenous
Malaria, Falciparum / drug therapy*
Quinine / administration & dosage,  adverse effects*
Treatment Outcome
Reg. No./Substance:
0/Antimalarials; 130-95-0/Quinine

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