Document Detail


Experience with a patient-friendly, mandatory, single-blastocyst transfer policy: the power of one.
MedLine Citation:
PMID:  21774925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether a mandatory single-blastocyst transfer (mSBT) algorithm reduced multiple gestation rates without sacrificing clinical pregnancy rates.
DESIGN: Retrospective review.
SETTING: U.S. university-based assisted reproductive technology (ART) program.
PATIENT(S): All women younger than 38 years undergoing their first ART cycle from 2009 to 2010 with ≥4 high-grade embryos on day 3 after oocyte retrieval (patients from 2009 were the "before" group, and patients completing ART under the mSBT policy in 2010 were the "after" group).
INTERVENTION(S): mSBT algorithm.
MAIN OUTCOME MEASURE(S): Multiple gestation and clinical pregnancy rates.
RESULT(S): Of the qualified patients, 136 women met inclusion criteria (62 from 2009, 74 from 2010). The baseline demographics were similar between the groups. Statistically significantly fewer blastocysts were transferred per patient in 2010 compared with 2009 (1.5 vs. 1.9). The clinical pregnancy rates before (67.7%) or after (63.5%) the mSBT policy were not statistically significantly different. Multiple gestation rates were statistically significantly reduced, from 43.8% (2009) to 14.6% (2010) after the mSBT policy was instituted. More patients from 2010 had ≥1 blastocyst cryopreserved compared with 2009 (52.9% vs. 30.6%).
CONCLUSION(S): A novel single-blastocyst transfer algorithm reduced multiple gestation rates and improved cryopreservation rates without compromising clinical pregnancy rates in good-prognosis patients.
Authors:
John M Csokmay; Micah J Hill; Rebecca J Chason; Sasha Hennessy; Aidita N James; Jacques Cohen; Alan H Decherney; James H Segars; Mark D Payson
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Publication Detail:
Type:  Journal Article     Date:  2011-07-20
Journal Detail:
Title:  Fertility and sterility     Volume:  96     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-01     Completed Date:  2011-11-08     Revised Date:  2014-08-20    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  580-4     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Blastocyst / cytology
Cryopreservation
Female
Humans
Infertility, Female / epidemiology*,  therapy*
Oocyte Retrieval / methods
Patient Satisfaction
Pregnancy
Pregnancy Outcome / epidemiology*
Pregnancy Rate
Pregnancy, Multiple / statistics & numerical data*
Prognosis
Retrospective Studies
Single Embryo Transfer / statistics & numerical data*
Grant Support
ID/Acronym/Agency:
ZIE HD008737-11/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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