| Experience with pancreatic transplantation in Stockholm. | |
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MedLine Citation:
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PMID: 6999838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight attempts at segmental pancreatic transplantation were made in 6 diabetic patients. While the indications for transplantation differed all the patients were severely incapacitated by the disease. None was uremic. The body and tail of the pancreas from cadaveric donors was used, the grafts were revascularized to the recipient's iliac vessles. Six of the grafts provided control of blood glucose for 7-51 days. Five of the grafts then failed owing to rejection, and one had to be removed while still functioning, because of arterial bleeding. Important lessons have been learned concerning both surgical and immunological aspects of this form of treatment : 1) Ducto-jejunostomy should be used to provide exocrine pancreatic drainage. 2) HLA-DR typing for donor-recipient selection and thoracic-duct drainage as an adjunctive immunosuppressive measure should be used to reduce the incidence of graft rejection. 3) An elevation of the postprandial blood glucose concentration is a first sign of rejection and should cause treatment. 4) Graft rejection can be reversed by conventional steroid medication. |
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Authors:
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C Groth; G Lundgren; R Gunnarsson; B Berg; P Arner; J Ostman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta medica Scandinavica. Supplementum Volume: 639 ISSN: 0365-463X ISO Abbreviation: Acta Med. Scand. Suppl. Publication Date: 1980 |
Date Detail:
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Created Date: 1980-12-18 Completed Date: 1980-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370331 Medline TA: Acta Med Scand Suppl Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 49-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diabetes Mellitus / surgery* Female Graft Rejection / drug effects HLA Antigens / immunology Histocompatibility Testing Humans Immunosuppression Male Middle Aged Pancreas Transplantation* Pancreatic Fistula / etiology, therapy Transplantation, Homologous / methods, mortality |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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