Document Detail

Experience with pancreatic transplantation in Stockholm.
MedLine Citation:
PMID:  6999838     Owner:  NLM     Status:  MEDLINE    
Eight attempts at segmental pancreatic transplantation were made in 6 diabetic patients. While the indications for transplantation differed all the patients were severely incapacitated by the disease. None was uremic. The body and tail of the pancreas from cadaveric donors was used, the grafts were revascularized to the recipient's iliac vessles. Six of the grafts provided control of blood glucose for 7-51 days. Five of the grafts then failed owing to rejection, and one had to be removed while still functioning, because of arterial bleeding. Important lessons have been learned concerning both surgical and immunological aspects of this form of treatment : 1) Ducto-jejunostomy should be used to provide exocrine pancreatic drainage. 2) HLA-DR typing for donor-recipient selection and thoracic-duct drainage as an adjunctive immunosuppressive measure should be used to reduce the incidence of graft rejection. 3) An elevation of the postprandial blood glucose concentration is a first sign of rejection and should cause treatment. 4) Graft rejection can be reversed by conventional steroid medication.
C Groth; G Lundgren; R Gunnarsson; B Berg; P Arner; J Ostman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica Scandinavica. Supplementum     Volume:  639     ISSN:  0365-463X     ISO Abbreviation:  Acta Med. Scand. Suppl.     Publication Date:  1980  
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370331     Medline TA:  Acta Med Scand Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
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MeSH Terms
Diabetes Mellitus / surgery*
Graft Rejection / drug effects
HLA Antigens / immunology
Histocompatibility Testing
Middle Aged
Pancreas Transplantation*
Pancreatic Fistula / etiology,  therapy
Transplantation, Homologous / methods,  mortality
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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