Document Detail

Experience with nalbuphine, a new opioid analgesic, in acute myocardial infarction.
MedLine Citation:
PMID:  3309298     Owner:  NLM     Status:  MEDLINE    
A total of 141 patients admitted to hospital with a diagnosis of suspected myocardial infarction were randomized to treatment with intravenous diamorphine (71) or nalbuphine (70). Myocardial infarction was subsequently confirmed in 109 patients. Both drugs provided good analgesia. Heart rate, blood pressure, respiratory rate, peak flow and minute volume were measured over a three-hour study period. Except for a slight fall in systolic blood pressure in the nalbuphine-treated group, there were no statistically significant differences between the groups. The nalbuphine-treated group had higher levels of aspartate aminotransferase and hydroxybutyric acid dehydrogenase but not creatine phosphokinase. The haemodynamic outcome and mortality at three months of the two groups were similar. It is concluded that nalbuphine provides effective analgesia coupled with few adverse circulatory or respiratory effects.
R A Greenbaum; G Kaye; P D Mason
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Royal Society of Medicine     Volume:  80     ISSN:  0141-0768     ISO Abbreviation:  J R Soc Med     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-11-03     Completed Date:  1987-11-03     Revised Date:  2010-09-09    
Medline Journal Info:
Nlm Unique ID:  7802879     Medline TA:  J R Soc Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  418-21     Citation Subset:  IM    
Royal Free Hospital and School of Medicine, London.
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MeSH Terms
Analgesics / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Hemodynamics / drug effects
Heroin / therapeutic use
Middle Aged
Morphinans / therapeutic use*
Myocardial Infarction / drug therapy*,  physiopathology
Nalbuphine / therapeutic use*
Prospective Studies
Random Allocation
Respiration / drug effects
Reg. No./Substance:
0/Analgesics; 0/Morphinans; 20594-83-6/Nalbuphine; 561-27-3/Heroin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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