| Experience with immunological tests in drug-induced hepatitis. | |
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MedLine Citation:
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PMID: 7032097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine patients are reported who developed hepatic injury following the administration of therapeutic agents. The drugs incriminated were prajmalium bitartrate (4 patients), quinidine (3 patients), procainamide and nifedipine (one patient each). In all patients the clinical features indicated an allergic process, which in three cases was substantiated by positive response to reexposure. The detection of immunologic processes in our patients by various in vitro methods supports the assumption that immune mechanisms may be involved in the production of drug-induced hepatic disease and confirm allergy. |
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Authors:
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H H Rotmensch; M Weintraub; G Sofferman; E Livni; A Klejman; M Liron |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zeitschrift für Gastroenterologie Volume: 19 ISSN: 0044-2771 ISO Abbreviation: Z Gastroenterol Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-02-12 Completed Date: 1982-02-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0033370 Medline TA: Z Gastroenterol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 691-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Drug Hypersensitivity / immunology* Drug-Induced Liver Injury / immunology*, pathology Female Fluorescent Antibody Technique Granuloma / pathology Humans Immunoglobulin A / analysis Immunoglobulin G / analysis Liver / pathology Male Microscopy, Electron Middle Aged Nifedipine / immunology Prajmaline / immunology Procainamide / immunology Quinidine / immunology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin G; 21829-25-4/Nifedipine; 35080-11-6/Prajmaline; 51-06-9/Procainamide; 56-54-2/Quinidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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