Document Detail

Experience with esmolol for the treatment of cocaine-associated cardiovascular complications.
MedLine Citation:
PMID:  1671639     Owner:  NLM     Status:  MEDLINE    
The authors report their experience using esmolol, an ultra-short acting beta-adrenergic antagonist, for the treatment of seven patients with cocaine-associated cardiovascular complications. No consistent hemodynamic benefit was found with the use of this drug. Although there was a decline in mean heart rate of 23% (range 0% to 35%), they were unable to show a consistent antihypertensive response. Adverse effects occurred in three patients. This included one patient with a marked exacerbation of hypertension and one who became hypotensive. Another patient developed emesis and lethargy during esmolol therapy and required endotracheal intubation. They do not recommend the routine use of esmolol for cocaine cardiotoxicity.
I C Sand; S L Brody; K D Wrenn; C M Slovis
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  9     ISSN:  0735-6757     ISO Abbreviation:  Am J Emerg Med     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-03-28     Completed Date:  1991-03-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-3     Citation Subset:  IM    
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303.
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MeSH Terms
Adrenergic beta-Antagonists / administration & dosage,  pharmacology,  therapeutic use*
Cardiovascular Diseases / drug therapy*,  etiology,  physiopathology
Emergency Service, Hospital*
Hemodynamics / drug effects
Hospitals, Teaching
Infusions, Intravenous
Injections, Intravenous
Middle Aged
Propanolamines / administration & dosage,  pharmacology,  therapeutic use*
Substance-Related Disorders / complications*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 50-36-2/Cocaine; 84057-94-3/esmolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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