Document Detail

Experience with injections of botulinum toxin type A into the detrusor muscle.
MedLine Citation:
PMID:  20094947     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: We evaluated the effects of intra-vesical injection of botulinum toxin type A in the detrusor muscle in patients with neurogenic overactive bladder (OAB), patients with non-neurogenic overactive bladder and patients with interstitial cystitis. MATERIALS AND METHODS: Between January 2003 and December 2006 we treated 30 patients with 100 I. U. to 300 I. U. of botulinum toxin A in the detrusor muscle. Patients were clinically and urodynamically followed up for 4, 12 and 36 weeks thereafter. RESULTS: Neurogenic overactive bladder: of the 19 injected doses, 18 (94.7%) in 7 patients were judged as effective, and 1 (5.2%) of 200 U of BTX-A was judged as ineffective. Mean bladder volume increased from 137 to 396 ml. Non-neurogenic overactive bladder: of 7 injections, 6 (85.7%) were judged effective in 5 patients. Mean bladder volume increased from 149 to 322 ml. Interstitial cystitis: in all 4 patients the treatments were deemed ineffective. CONCLUSIONS: Injecting 300 units of BTX-A into 30 sites in the muscle located in the body of the bladder region is effective for neurogenic bladder patients with intermittent catheterization who have urge and reflective types of incontinence. Injections of 100 and 200 units of BTX-A to treat non-neurogenic overactive bladder with urinary incontinence provided together without retention. The optimal dose of BTX-A requires further investigation. Injection with 200 units of BTX-A was not useful against interstitial cystitis. None of the patients developed any adverse effects after injecting the bladder wall with BTX-A.
I Miyagawa; T Watanabe; T Isoyama; M Honda; N Kobayasi; K Hikita; M Saito; S Hirakawa
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Publication Detail:
Type:  Journal Article     Date:  2010-01-21
Journal Detail:
Title:  Aktuelle Urologie     Volume:  41 Suppl 1     ISSN:  1438-8820     ISO Abbreviation:  Aktuelle Urol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421406     Medline TA:  Aktuelle Urol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  S24-6     Citation Subset:  IM    
Department of Urology, Tottori University School of Medicine, Yonago, Japan.
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MeSH Terms
Botulinum Toxin Type A / administration & dosage*
Dose-Response Relationship, Drug
Follow-Up Studies
Injections, Intramuscular
Middle Aged
Urinary Bladder / drug effects
Urinary Bladder, Neurogenic / drug therapy*
Urinary Bladder, Overactive / drug therapy*
Urinary Incontinence / drug therapy*
Urodynamics / drug effects
Reg. No./Substance:
0/Botulinum Toxin Type A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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