Document Detail


Experience using liver transplantation for the treatment of severe bile duct injuries over 20 years in Argentina: results from a National Survey.
MedLine Citation:
PMID:  21762297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Bile duct injury (BDI) is a severe complication that may arise during the surgical treatment of benign disease and a few patients will develop end-stage liver disease (ESLD) requiring a liver transplant (LT). Objective: Analyse the experience using LT as a definitive treatment of BDI in Argentina.
PATIENTS AND METHODS: A national survey regarding the experience of LT for BDI.
RESULTS: Sixteen out 18 centres reported a total of 19 patients. The percentage of LT for BDI from the total number of LT per period was: 1990-94 = 3.1%, 1995-99 = 1.6%, 2000-04 = 0.7% and 2005-09 = 0.2% (P < 0.001). The mean age was 45.7 ± 10.3 years (range 26-62) and 10 patients were female. The BDI occurred during cholecystectomy in 16 and 7 had vascular injuries. One patient presented with acute liver failure and the others with chronic ESLD. The median time between BDI and LT was 71 months (range 0.2-157). The mean follow-up was 8.3 years (10 months to 16.4 years). Survival at 1, 3, 5 and 10 years was 73%, 68%, 68% and 45%, respectively.
CONCLUSIONS: The use of LT for the treatment of BDI declined over the review period. LT plays a role in selected cases in patients with acute liver failure and ESLD.
Authors:
Victoria Ardiles; Lucas McCormack; Emilio Quiñonez; Nicolás Goldaracena; Juan Mattera; Juan Pekolj; Miguel Ciardullo; Eduardo de Santibañes
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2011-06-24
Journal Detail:
Title:  HPB : the official journal of the International Hepato Pancreato Biliary Association     Volume:  13     ISSN:  1477-2574     ISO Abbreviation:  HPB (Oxford)     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-18     Completed Date:  2011-11-23     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100900921     Medline TA:  HPB (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  544-50     Citation Subset:  IM    
Copyright Information:
© 2011 International Hepato-Pancreato-Biliary Association.
Affiliation:
General Surgery Service and Liver Transplant Unit, Hospital Italiano de Buenos Aires General Surgery and Liver Transplant Unit, Hospital Alemán de Buenos Aires, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Adult
Argentina
Bile Ducts / injuries*
Chi-Square Distribution
Cholecystectomy / adverse effects
Digestive System Surgical Procedures / adverse effects*,  mortality
End Stage Liver Disease / etiology,  mortality,  surgery*
Female
Health Care Surveys
Hepatectomy / adverse effects
Humans
Iatrogenic Disease
Liver Failure, Acute / etiology,  mortality,  surgery*
Liver Transplantation* / adverse effects,  mortality
Male
Middle Aged
Retrospective Studies
Risk Assessment
Risk Factors
Survival Analysis
Time Factors
Treatment Outcome
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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