| Experience in neonatal screening for congenital hypothyroidism. | |
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MedLine Citation:
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PMID: 8325147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From November 1986 to June 1991, 91,683 neonates were screened for congenital hypothyroidism by measuring thyroid-stimulating hormone (TSH). 10,284 neonates were screened with chemical luminoimmunoassay (CLIA), and 80,399 screened with time-resolved fluoroimmunoassay (DELFIA). The critical value of TSH was 20 mU/L. Twenty cases were confirmed to be congenital hypothyroidism. The incidence was 1:4584, with a female to male ratio of 3:2. These patients were treated with thyroid gland desiccant, with a dosage equivalent to L-thyroxin 5-7.5 micrograms/kg/day. Their physical growth and intellectual ability were normal. 81,201 dried blood specimens were tested in single for TSH by DELFIA and T4, T3 and TSH serum testing for those with elevated TSH. No false negative and missing case was found after the screening program started. When frequent fluctuation of T4 and TSH concentration occurred at normal level in some infants, it is better to wait and have a close observation, however the treatment must be started before 3 months of age to avoid the risk of mental retardation. |
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Authors:
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Y Q Zhang; Q X Cao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 106 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-08-06 Completed Date: 1993-08-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: CHINA |
Other Details:
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Languages: eng Pagination: 216-9 Citation Subset: IM |
Affiliation:
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Neonatal Screening Center, Shanghai Children's Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Congenital Hypothyroidism* Female Fluoroimmunoassay / methods Humans Hypothyroidism / complications, drug therapy Infant, Newborn Male Mental Retardation / etiology, prevention & control Neonatal Screening* Thyroid Extract, Desiccated / therapeutic use Thyrotropin / blood Thyroxine / blood |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Extract, Desiccated; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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