| Experience-dependent asymmetric variation in primate prefrontal morphology. | |
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MedLine Citation:
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PMID: 12385789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Theories of human development suggest that experiences embedded in social relationships alter prefrontal brain systems that mediate emotional self-regulation. This study tests for experience-dependent effects on prefrontal gray and white matter volumes determined in 39 young adult monkeys (Saimiri sciureus) 4 years after conditions that modified early maternal availability. These conditions were previously shown to alter subsequent measures of emotional behavior, social propensities, and hypothalamic-pituitary-adrenal axis stress physiology. Here we identify significant differences in right but not left adult prefrontal volumes, with experience-dependent asymmetric variation most clearly expressed in ventral medial cortex measured in vivo by magnetic resonance imaging (MRI). Follow-up studies now need to determine whether maternal availability directly affects or interacts with subsequent experiences to alter prefrontal substrates of emotional processing and sensitivity to stress. |
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Authors:
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David M Lyons; Hagop Afarian; Alan F Schatzberg; Anne Sawyer-Glover; Michael E Moseley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Behavioural brain research Volume: 136 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-18 Completed Date: 2002-11-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 51-9 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Science, Psychiatry Neuroscience, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, CA 94305-5485, USA. dmlyons@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / physiology Female Functional Laterality / physiology* Hippocampus / physiology Hypothalamo-Hypophyseal System / physiology Magnetic Resonance Imaging Male Maternal Deprivation Organ Size / physiology Prefrontal Cortex / anatomy & histology* Saimiri Sex Characteristics Social Environment* |
| Grant Support | |
ID/Acronym/Agency:
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MH47573/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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