Document Detail


An expeditious route to eight-membered heterocycles by nickel-catalyzed cycloaddition: low-temperature C(sp)2-C(sp)3 bond cleavage.
MedLine Citation:
PMID:  22806996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A cool break: 3-Azetidinone and a variety of diynes undergo a cycloaddition reaction catalyzed by Ni/IPr to give dihydroazocine compounds (see scheme; IPr=1,3-bis(2,6-diisopropylphenyl)imidazolidene). The reaction involves a challenging C(sp)2-C(sp)3 bond cleavage step, yet, surprisingly, proceeds at low temperature.
Authors:
Puneet Kumar; Kainan Zhang; Janis Louie
Related Documents :
22903436 - A synthon for a 14-electron ir(iii) species: catalyst for highly selective β-(z) hydro...
12939486 - Reactions of the ionized enol tautomer of acetanilide: elimination of hnco via a novel ...
16182436 - Retention of gases by hexadecyltrimethylammonium-montmorillonite clays.
12772296 - Low-temperature ir and nmr studies of the interaction of group 8 metal dihydrides with ...
23795066 - 6,12-bis[(tri-cyclo-hexyl-sil-yl)ethyn-yl]indeno-[1,2-b]fluorene.
8593626 - Lipo-oligosaccharide of the campylobacter lari type strain atcc 35221. structure of the...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-07-17
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  51     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-14     Completed Date:  2013-03-12     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  8602-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry, University of Utah, 315 South, 1400 East, Salt Lake City, Utah 84112-0850, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alkynes / chemistry*
Azetidines / chemistry*
Catalysis
Cycloaddition Reaction
Heterocyclic Compounds / chemical synthesis*,  chemistry
Nickel / chemistry*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
5R01GM076125/GM/NIGMS NIH HHS; R01 GM076125/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/2-azetidinone; 0/Alkynes; 0/Azetidines; 0/Heterocyclic Compounds; 7440-02-0/Nickel
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diet and physical activity among migrant Bougainvilleans in Port Moresby, Papua New Guinea: Associat...
Next Document:  Cerebral blood flow and gray matter volume covariance patterns of cognition in aging.