Document Detail


Expedient synthesis of N-Z-pyroglutamyl-amino acid derivatives.
MedLine Citation:
PMID:  17845849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-Z-pyroglutamyl pseudopeptides 3a-c are shown to be conveniently prepared from glutamyl-bis-Bt 1a by cyclization of an N-terminal glutamic acid residue. Structures are supported by 2D NMR studies and by comparison with the same products prepared by direct coupling of the C-terminus activated N-pGlu 1b and free amino acids 2a-c.
Authors:
Alan R Katritzky; Parul Angrish; Ekaterina Todadze; Ion Ghiviriga
Related Documents :
6128059 - Specific binding of [3h]l-glutamate to cerebellar membranes: evidence for recognition s...
6884989 - The primary structure of the glycan moiety of pseudomurein from methanobacterium thermo...
15355319 - Monocarboxylate transport inhibition alters retinal function and cellular amino acid le...
10078989 - Effects of bilobalide on gamma-aminobutyric acid levels and glutamic acid decarboxylase...
16665749 - N-ammonia assimilation, 2-oxoglutarate transport, and glutamate export in spinach chlor...
24672789 - Animal model of acid-reflux esophagitis: pathogenic roles of acid/pepsin, prostaglandin...
9224339 - Use of polyglycolic acid mesh to support parenchymal closure following partial nephrect...
11942699 - Serotonin modulates oscillations of the membrane potential in isolated spinal neurons f...
10493789 - Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and second...
Publication Detail:
Type:  Journal Article     Date:  2007-08-19
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  17     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  6000-2     Citation Subset:  IM    
Affiliation:
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemical synthesis*
Magnetic Resonance Spectroscopy
Pyrrolidonecarboxylic Acid / chemistry*
Chemical
Reg. No./Substance:
0/Amino Acids; 98-79-3/Pyrrolidonecarboxylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for th...
Next Document:  Inhibitors of NF-kappaB derived from thalidomide.