Document Detail

Expedient synthesis of N-Z-pyroglutamyl-amino acid derivatives.
MedLine Citation:
PMID:  17845849     Owner:  NLM     Status:  MEDLINE    
N-Z-pyroglutamyl pseudopeptides 3a-c are shown to be conveniently prepared from glutamyl-bis-Bt 1a by cyclization of an N-terminal glutamic acid residue. Structures are supported by 2D NMR studies and by comparison with the same products prepared by direct coupling of the C-terminus activated N-pGlu 1b and free amino acids 2a-c.
Alan R Katritzky; Parul Angrish; Ekaterina Todadze; Ion Ghiviriga
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Publication Detail:
Type:  Journal Article     Date:  2007-08-19
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  17     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  6000-2     Citation Subset:  IM    
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
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MeSH Terms
Amino Acids / chemical synthesis*
Magnetic Resonance Spectroscopy
Pyrrolidonecarboxylic Acid / chemistry*
Reg. No./Substance:
0/Amino Acids; 98-79-3/Pyrrolidonecarboxylic Acid

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